| Author | Vieira, Paula Melo de Abreu | |
| Author | Francisco, Amanda Fortes | |
| Author | Machado, Evandro Marques de Menezes | |
| Author | Nogueira, Nívia Carolina | |
| Author | Fonseca, Katia da Silva | |
| Author | Reis, Alexandre Barbosa | |
| Author | Carvalho, Andréa Teixeira de | |
| Author | Martins Filho, Olindo Assis | |
| Author | Tafuri, Washington Luiz | |
| Author | Carneiro, Cláudia Martins | |
| Access date | 2014-02-18T12:37:39Z | |
| Available date | 2014-02-18T12:37:39Z | |
| Document date | 2012 | |
| Citation | ABREU VIEIRA, Paula Melo ET AL. Different infective forms trigger distinct immune response in experimental Chagas disease. Plos One. 2012; 7(3)e32912 | pt_BR |
| ISSN | 1932-6203 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7317 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Title | Different infective forms trigger distinct immune response in experimental Chagas disease | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pone.0032912 | |
| Abstract | Although metacyclic and blood trypomastigotes are completely functional in relation to parasite-host interaction and/or target cell invasion, they differ in the molecules present on the surface. Thus, aspects related to the variability that the forms of T. cruzi interacts with host cells may lead to fundamental implications on the immune response against this parasite and, consequently, the clinical evolution of Chagas disease. We have shown that BT infected mice presented higher levels of parasitemia during all the acute phase of infection. Moreover, the infection with either MT or BT forms resulted in increased levels of total leukocytes, monocytes and lymphocytes, specifically later for MT and earlier for BT. The infection with BT forms presented earlier production of pro inflammatory cytokine TNF- a and later of IFN-c by both T cells subpopulations.
This event was accompanied by an early cardiac inflammation with an exacerbation of this process at the end of the acute phase. On the other hand, infection with MT forms result in an early production of IFN-c , with subsequent control in the production of this cytokine by IL-10, which provided to these animals an immunomodulatory profile in the end of the acute phase. These results are in agreement with what was found for cardiac inflammation where animals infected with MT forms showed intense cardiac inflammation later at infection, with a decrease in the same at the end of this phase. In summary, our findings emphasize the importance of taking into account the inoculums source of T. cruzi , since vectorial or transfusional routes of T. cruzi infection may trigger distinct parasite-host interactions during the acute phase that may influence relevant biological aspects of chronic Chagas disease | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Nucleo de Pesquisas em Ciencias Biologicas. Laboratorio de Imunopatologia,, Ouro Preto, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Nucleo de Pesquisas em Ciencias Biologicas. Laboratorio de Imunopatologia,, Ouro Preto, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Nucleo de Pesquisas em Ciencias Biologicas. Laboratorio de Doença de Chagas, Ouro Preto, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Nucleo de Pesquisas em Ciencias Biologicas. Laboratorio de Imunopatologia, Ouro Preto, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Nucleo de Pesquisas em Ciencias Biologicas. Laboratorio de Imunopatologia, Ouro Preto, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Nucleo de Pesquisas em Ciencias Biologicas. Laboratorio de Imunopatologia,, Ouro Preto, MG, Brazil/Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Analises Clınicas. Ouro Preto, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoração. Belo Horizonte, MG, Brazil, | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoração. Belo Horizonte, MG, Brazil, | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Nucleo de Pesquisas em Ciencias Biologicas. Laboratorio de Imunopatologia, Ouro Preto, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Nucleo de Pesquisas em Ciencias Biologicas. Laboratorio de Imunopatologia,, Ouro Preto, MG, Brazil/Universidade Federal de Ouro Preto.Escola de Farmácia. Departamento de Analises Clınicas. Ouro Preto, MG, Brazil, | pt_BR |
| Subject | Chagas disease | pt_BR |
