| Author | Araújo, Juliano Michel de | |
| Author | Melo, Tatiane Teixeira de | |
| Author | Sena, Isabela Campos de | |
| Author | Alves, Clarice Carvalho | |
| Author | Araújo, Neusa | |
| Author | Durães, Fernanda do Valle | |
| Author | Oliveira, Sérgio Costa | |
| Author | Fonseca, Cristina Toscano | |
| Access date | 2014-02-25T16:03:35Z | |
| Available date | 2014-02-25T16:03:35Z | |
| Document date | 2012 | |
| Citation | ARAUJO, Juliano Michel et al. Schistosoma mansoni schistosomula tegument (Smteg) immunization in absence of adjuvant induce IL-10 production by CD4+ cells and failed to protect mice against challenge infection. Acta Tropica. 2012, vol.124, pp. 140-146 | pt_BR |
| ISSN | 0001-706X | |
| URI | https://www.arca.fiocruz.br/handle/icict/7351 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Schistosoma mansoni schistosomula tegument (Smteg) immunization in absence of adjuvant induce IL-10 production by CD4+ cells and failed to protect mice against challenge infection | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.actatropica.2012.07.007 | |
| Abstract | The Schistosoma mansoni tegument interaction with the immune system plays a key role in disease establishment or elimination. We have recently demonstrated that S. mansoni schistosomula tegument (Smteg) is able to activate innate immune response and to induce protective immunity in a vaccine formulation with Freunds adjuvant. In this work, we evaluated the ability of Smteg to elicit protection in the absence of adjuvant. Smteg mice immunization resulted in significant antibody production, increased percentage of CD4+IFN-g+ and CD4+IL-10+ cells in spleen and increased production of IFN-g and IL-10 by spleen cells, but failed to reduce parasite burden, female fecundity and morbidity. We also demonstrated that BMDC stimulation with Smteg resulted in significant IL-10 production. Our results demonstrate that Smteg has immune modulatory proprieties | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciências e Tecnologia em Doenças Tropicais. Brasil | pt_BR |
| Subject | Schistosoma mansoni | pt_BR |
| Subject | Schistosomula tegument | pt_BR |
| Subject | Immunization | pt_BR |
| Subject | Regulatory response | pt_BR |
