| Author | Oliveira, Fabiano | |
| Author | Bafica, Andre Luiz Barbosa | |
| Author | Rosato, Andréa Bomura | |
| Author | Favali, Cecilia Beatriz Fiuza | |
| Author | Costa, Jackson Mauricio Lopes | |
| Author | Cafe, Virginia | |
| Author | Barral Netto, Manoel | |
| Author | Barral, Aldina Maria Prado | |
| Access date | 2014-02-27T13:47:41Z | |
| Available date | 2014-02-27T13:47:41Z | |
| Document date | 2011 | |
| Citation | OLIVEIRA, F. et al. Lesion size correlates with Leishmania antigen-stimulated TNF-levels in human cutaneous leishmaniasis. American Journal of Tropical Medicine and Hygiene, v. 85, n. 1, p. 70-73, 2011 | pt_BR |
| ISSN | 1476-1645 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7367 | |
| Language | eng | pt_BR |
| Publisher | The American Society of Tropical Medicine and Hygiene | pt_BR |
| Rights | open access | pt_BR |
| Title | Lesion size correlates with Leishmania antigen-stimulated TNF-levels in human cutaneous leishmaniasis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.4269/ajtmh.2011.10-0680 | |
| Abstract | Cutaneous leishmaniasis (CL) is a worldwide disease endemic in several regions of the globe. The hallmark
of CL is skin ulcers likely driven by efforts of the immune system to control Leishmania growth. Cytokines, such as
tumor necrosis factor (TNF) and interferon-gamma can control disease progression in animal models. Nevertheless, the
impact of these cytokines in CL ulcer outcome is not well established in humans. In this study, 96 CL patients from an
endemic area of Leishmania braziliensis were enrolled for a follow-up study that consisted of clinical and immunological
evaluations in a 2-year period. Statistical analysis revealed that healing time ( P = 0.029), age ( P = 0.002), and TNF levels
( P = 0.0002) positively correlate with ulcer size at the time of the first clinical evaluation. Our findings suggest that ulcer
size correlates with healing time and TNF levels support the use of TNF inhibitors combined with standard therapy to
improve healing in CL patients with severe lesions | pt_BR |
| Affilliation | National Institutes of Health. Laboratory of Malaria and Vector Research. Rockville, MD | pt_BR |
| Affilliation | Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Florianopolis, SC, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade de Brasília. Instituto de Ciencias Biologicas. Departamento de Biologia Celular. Brasilia, DF, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imuno-regulação. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia - iii - INCT. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia - iii - INCT. Salvador, BA, Brasil | pt_BR |
| DeCS | Antígenos de Protozoários/imunologia | pt_BR |
| DeCS | Leishmania/imunologia | pt_BR |
| DeCS | Leishmaniose Cutânea/patologia | pt_BR |
| DeCS | Fator de Necrose Tumoral alfa/metabolismo | pt_BR |
| DeCS | Adolescente | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Idoso | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Leishmaniose Cutânea/metabolismo | pt_BR |
| DeCS | Meia-Idade | pt_BR |
| DeCS | Masculino | pt_BR |
