| Autor | Bacellar, Maria Olívia Amado Ramos | |
| Autor | Brodskyn, Claudia Ida | |
| Autor | Guerreiro, Jaqueline | |
| Autor | Barral Netto, Manoel | |
| Autor | Costa, Carlos Henrique Nery | |
| Autor | Coffman, Robert L | |
| Autor | Johnson Junior, Warren D | |
| Autor | Carvalho Filho, Edgar Marcelino | |
| Data de acesso | 2014-03-26T14:27:51Z | |
| Data de disponibilização | 2014-03-26T14:27:51Z | |
| Data do publicação | 1996 | |
| Citação | BACELLAR O. et al. Interleukin-12 restores interferon-gamma production and cytotoxic responses in visceral leishmaniasis. The Journal of Infectious Diseases, v. 173, n. 6, p. 1515-1518, 1996. | pt_BR |
| ISSN | 0022-1899 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7450 | |
| Idioma | eng | pt_BR |
| Editor | The University of Chicago | pt_BR |
| Direito Autoral | open access | pt_BR |
| Título | Interleukin-12 restores interferon-gamma production and cytotoxic responses in visceral leishmaniasis | pt_BR |
| Tipo do documento | Article | pt_BR |
| Resumo em Inglês | American visceral leishmaniasis (AVL) is associated with the absence of lymphocyte proliferative
responses and interleukin (IL)-2 and interferon-y (IFN-y) production upon stimulation with Leishmania
antigen. In contrast, cure of AVL is associated with restoration of these T cell functions. In
the present study, the ability of IL-12, a cytokine that acts on NK and T cells to restore cellular
immune responses in AVL, was evaluated. Participants of the study included 12 patients with AVL
and 7 subjects cured of AVL. The [3H]thymidine uptake and IFN-y production in cultures of
peripheral blood mononuclear cells (from AVLpatients) stimulated with Leishmaniachagasi antigen
were 882 ± 1393cpm and zero, respectively. Addition of IL-12 enhanced the proliferative response
to 5097 ± 6429 cpm (P < .001) and IFN-y production to 305 ± 325 pglmL (P < .01). IL-12 also
restored cytotoxic activity against the K562 cell line. These results indicate that IL-12 has an
important role in the regulation of the cellular immune response in human leishmaniasis. | pt_BR |
| Afiliação | Federal University of Bahia. Immunology Service of Hospital Universitario Professor Edgard Santos. Salvador, BA, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Mycobacteria. Salvador, BA, Brasil | pt_BR |
| Afiliação | Federal University of Piaui. Hospital de Doencas Infecto-Contagiosas. Teresina, PI, Brazil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Mycobacteria. Salvador, BA, Brasil | pt_BR |
| Afiliação | Federal University of Piaui. Hospital de Doencas Infecto-Contagiosas. Teresina, PI, Brazil | pt_BR |
| Afiliação | DNAX Research Institute. Department of Immunology.Palo Alto, California | pt_BR |
| Afiliação | Cornell University Medical College. Division of International Medicine and Infectious Diseases. New York, New York | pt_BR |
| Afiliação | Federal University of Bahia. Immunology Service of Hospital Universitario Professor Edgard Santos. Salvador, BA, Brasil | pt_BR |
| DeCS | Citotoxicidade Imunológica/imunologia | pt_BR |
| DeCS | Interferon gama/biossíntese | pt_BR |
| DeCS | Interleucina-12/farmacologia | pt_BR |
| DeCS | Leishmaniose Visceral/imunologia | pt_BR |
| DeCS | Ativação Linfocitária/imunologia | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Antígenos de Protozoários/imunologia | pt_BR |
| DeCS | Células Cultivadas | pt_BR |
| DeCS | DNA/biossíntese | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Interleucina-10/imunologia | pt_BR |
| DeCS | Leishmania infantum/imunologia | pt_BR |
| DeCS | Leucócitos Mononucleares/imunologia | pt_BR |
| DeCS | Proteínas Recombinantes/farmacologia | pt_BR |
