Author | Soares, Luciane Marieta | |
Author | Macedo, Júlio Oliveira | |
Author | Azevedo, Everton Cruz de | |
Author | Santos, Cleiton Silva | |
Author | Sampaio, Marina de Queiroz | |
Author | Santos, Andréia Carvalho dos | |
Author | Reis, Mitermayer Galvão dos | |
Author | Athanazio, Daniel Abensur | |
Access date | 2014-03-31T16:54:58Z | |
Available date | 2014-03-31T16:54:58Z | |
Document date | 2014 | |
Citation | SOARES, L. M. et al. Immunomodulatory treatment with thalidomide in experimental leptospirosis in Golden Syrian hamsters (Mesocricetus auratus). Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 108, n. 2, p. 105-111, 2014. | pt_BR |
ISSN | 1878-3503 | |
URI | https://www.arca.fiocruz.br/handle/icict/7473 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | open access | pt_BR |
Title | Immunomodulatory treatment with thalidomide in experimental leptospirosis in Golden Syrian hamsters (Mesocricetus auratus) | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/trstmh/trt112 | |
Abstract | BACKGROUND: The benefit of antibiotics in leptospirosis is limited when treatment is started four days after symptoms appear, and new adjuvant therapeutic options are urgently needed. METHODS: Hamsters (Mesocricetus auratus) were infected by Leptospira interrogans strain L1-130, and groups were assigned based on no treatment (NONE), thalidomide only (TAL), ampicillin only (AMP) or both (AMP-TAL). Treatment was started two days after the onset of symptoms (experiment 1) and immediately after detection of the first death (experiment 2). RESULTS: Experiment 1: all hamsters from the groups AMP and AMP-TAL survived (n=8), while all hamsters from groups NONE (n=6) and TAL (n=8) died. The AMP and the AMP-TAL groups showed no renal or liver pathology and absent or very low leptospiral burden in target organs. Experiment 2: lethal outcome was observed in 6/6 hamsters in the NONE group, 8/8 in the TAL group, and 6/8 in both the AMP and AMP-TAL groups. Thalidomide showed no survival benefit when compared to hamsters treated with ampicillin alone. The TAL, AMP and AMP-TAL groups had very low tissue leptospiral counts. CONCLUSION: Thalidomide had minimal impact on survival in the late treatment of leptospirosis hamster model. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Subject | Animal disease models | pt_BR |
Subject | Leptospira | pt_BR |
Subject | Leptospirosis | pt_BR |
Subject | Mesocricetus auratus | pt_BR |
Subject | Thalidomide | pt_BR |