Author | Zarife, Maria Alice Sant’Anna | |
Author | Reis, Eliana Almeida Gomes | |
Author | Meira, Glenda C | |
Author | Carmo, Theomira Mauadie de Azevedo | |
Author | Lopes, Gisele Barreto | |
Author | Malafaia, Emilia C. O. B | |
Author | Silva, Helder Reis | |
Author | Santana, Nelma Pereira de | |
Author | Martins Filho, Olindo Assis | |
Author | Reis, Mitermayer Galvão dos | |
Access date | 2014-04-07T17:40:22Z | |
Available date | 2014-04-07T17:40:22Z | |
Document date | 2011 | |
Citation | IL-8 is associated with non-viremic state and IFN-γ with biochemical activity in HCV-seropositive blood donors. | pt_BR |
ISSN | 1423-0100 | |
ISSN | 10.1159/000318896 | |
URI | https://www.arca.fiocruz.br/handle/icict/7500 | |
Language | eng | pt_BR |
Publisher | S Karger AG Brasil | pt_BR |
Rights | open access | pt_BR |
Title | IL-8 is associated with non-viremic state and IFN-γ with biochemical activity in HCV-seropositive blood donors. | pt_BR |
Type | Article | pt_BR |
Abstract | The aim of this study was to explore a possible association between the pattern of serum cytokines with the virological and biochemical status of hepatitis C virus (HCV)-seropositive blood donors. METHODS: 23 non-viremic and 33 viremic HCV-seropositive blood donors based on HCV-RNA tests, and 29 healthy individuals were included. Cytometric bead array assays were performed to detect cytokines. RESULTS: The subjects were classified as low, medium or high cytokine producers based on the tertile distribution. The absence of detectable viremia was associated with high IL-1ß and IL-8 producers. Conversely, elevated levels of IL-6, IL-10 and IL-12 were associated with detectable viremia. An increased frequency of high IL-1ß producers was observed frequently in the non-viremic recombinant immunoblot assay (RIBA)-indeterminate subjects, while the high IL-4, IL-6, IL-8, IL-10 and IL-12 producers were more frequent in the non-viremic RIBA-positive subjects. Furthermore, the levels of IL-1ß and IL-8 were higher in viremic subjects with a low level of alanine-aminotransferase (ALT), whereas the level of IFN-γ was increased among viremic subjects with a high ALT level. CONCLUSION: IL-1ß and IL-8 were more likely to be associated with a non-viremic or less severe HCV infection, whereas IL-2 and IFN-γ levels correlated with a high ALT level. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Laboratório Central de Saúde Pública, LACEN-BA. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | HEMOBA. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Hepatitis C virus | pt_BR |
Subject | Blood donors | pt_BR |
Subject | Inflammatory and regulatory | pt_BR |
Subject | Cytokines | pt_BR |
Subject | Serological status | pt_BR |
Subject | Virological status | pt_BR |
Subject | Alanine aminotransferase | pt_BR |
DeCS | Doadores de Sangue | pt_BR |
DeCS | Hepacivirus/isolamento & purificação | pt_BR |
DeCS | Hepatite C/diagnóstico | pt_BR |
DeCS | Hepatite C/virologia | pt_BR |
DeCS | Interferon gama/sangue | pt_BR |
DeCS | Interleucina-8/sangue | pt_BR |
DeCS | Viremia/diagnóstico | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Hepacivirus/imunologia | pt_BR |
DeCS | Hepatite C/imunologia | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | RNA Viral/sangue | pt_BR |