| Author | Faria, Marcos Tucunduva de | |
| Author | Athanazio, Daniel Abensur | |
| Author | Ramos, Eduardo Antônio Gonçalves | |
| Author | Silva, Edward Felix | |
| Author | Reis, Mitermayer Galvão dos | |
| Author | Ko, Albert Icksang | |
| Access date | 2014-04-25T17:47:57Z | |
| Available date | 2014-04-25T17:47:57Z | |
| Document date | 2007 | |
| Citation | FARIA, M. T. et al. Morphological alterations in the kidney of rats with natural and experimental Leptospira infection. Journal of Comparative Pathology, v. 137, n. 4, p. 231-238, 2007. | pt_BR |
| ISSN | 0021-9975 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7544 | |
| Language | eng | pt_BR |
| Publisher | Elsevier Ltd. | pt_BR |
| Rights | open access | pt_BR |
| Title | Morphological alterations in the kidney of rats with natural and experimental Leptospira infection. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.jcpa.2007.08.001 | |
| Abstract | Leptospirosis is a widespread anthropozoonosis, with a broad array of mammalian reservoirs, occurring as rural endemics, urban outbreaks related to floods, and emergent disease associated with water sports and recreational exposure in developed countries. Rats are the major source of human infection, particularly in urban areas; however few reports have focused on the pathology of leptospirosis in this host. This study reports pathological changes in 60 kidneys from captured wild rats and compares these with changes in the kidney of Wistar rats experimentally infected with Leptospira interrogans serovar Copenhageni strain FIOCRUZ L1-130. A broad range of morphological alterations were detected in the kidneys from captured rats but interstitial nephritis was the only feature reproduced under experimental conditions. The role of interstitial nephritis in the pathogenesis of leptospirosis is reviewed and it is suggested that rats may provide a potential tool for the study of colonization mechanisms and host resistance in acute leptospiral disease. | pt_BR |
| Affilliation | Embrapa Amazonia Oriental. Belem, PA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, Brasil / Federal University of Pelotas. Pelotas, RS, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Division of International Medicine and Infectious Disease.WeillMedical College of Cornell University. NewYork,NY,USA | pt_BR |
| Subject | leptospirosis | pt_BR |
| Subject | Rattus norvegicus | pt_BR |
| Subject | Interstitial nephritis | pt_BR |
| Subject | kidney | pt_BR |
| DeCS | Rim/patologia | pt_BR |
| DeCS | Leptospira interrogans | pt_BR |
| DeCS | Leptospirose/patologia | pt_BR |
| DeCS | Leptospirose/veterinária | pt_BR |
| DeCS | Doenças dos Roedores/patologia | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Modelos Animais de Doenças | pt_BR |
| DeCS | Técnica Indireta de Fluorescência para Anticorpo | pt_BR |
| DeCS | Nefrite Intersticial/microbiologia | pt_BR |
| DeCS | Nefrite Intersticial/patologia | pt_BR |
| DeCS | Ratos | pt_BR |
| DeCS | Ratos wistar | pt_BR |
