Author | Reis, Eliana Almeida Gomes | |
Author | Athanazio, Daniel Abensur | |
Author | Lima, Isabella | |
Author | Silva, Natália Oliveira e | |
Author | Andrade, Jorge Clarêncio de Souza | |
Author | Jesus, Ronden N | |
Author | Barbosa, Lúcio Macedo | |
Author | Reis, Mitermayer Galvão dos | |
Author | Santiago, Mittermayer Barreto | |
Access date | 2014-05-06T14:11:06Z | |
Available date | 2014-05-06T14:11:06Z | |
Document date | 2009 | |
Citation | REIS, E. A. G. et al. NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis. Rheumatology International, v. 29, n. 4, p. 469-475, 2009. | pt_BR |
ISSN | 1437-160X | |
ISSN | 10.1007/s00296-008-0719-0 | |
URI | https://www.arca.fiocruz.br/handle/icict/7585 | |
Language | eng | pt_BR |
Publisher | Springer International | pt_BR |
Rights | open access | pt_BR |
Title | NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis | pt_BR |
Type | Article | pt_BR |
Abstract | Biomarkers of clinical response to rituximab (RTX) therapy and early predictors of outcome are still under investigation. We report a flow cytometric immunophenotyping analysis from peripheral blood leukocyte subpopulations of two patients with systemic lupus erythematosus (SLE) associated thrombocytopenia and one patient with rheumatoid arthritis (RA), before and after 6 weeks of treatment with RTX. Our results show a reduced population of CD19(+) expressing cells (B cells) after RTX treatment in all three patients. Increased frequency of peripheral regulatory CD4(+)CD25(high) T cell subset and the CD3(-)CD16(-)CD56(bright) NK cell subset after RTX therapy were also observed in all patients, the latter being more pronounced in the SLE patient with sustained clinical response. In addition, an increased population of NKT cell subsets was observed in the patients with clinical response. This is the first evaluation of NK and NKT cells as biomarkers of clinical response after rituximab therapy in rheumatic diseases | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Serviço de Reumatologia do Hospital Santa Izabel. Salvador, BA, Brasil | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública (Medical School). Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública (Medical School). Salvador, BA, Brasil | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública (Medical School). Salvador, BA, Brasil | pt_BR |
Subject | Systemic lupus erythematosus | pt_BR |
Subject | Rheumatoid arthritis | pt_BR |
Subject | Natural killer cells | pt_BR |
Subject | Rituximab | pt_BR |
DeCS | Anticorpos Monoclonais/uso terapêutico | pt_BR |
DeCS | Antirreumáticos/uso terapêutico | pt_BR |
DeCS | Artrite Reumatoide/quimioterapia | pt_BR |
DeCS | Lúpus Eritematoso Sistêmico/quimioterapia | pt_BR |
DeCS | Células T Matadoras Naturais/imunologia | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Anticorpos Monoclonais/imunologia | pt_BR |
DeCS | Anticorpos Monoclonais Murinos | pt_BR |
DeCS | Antirreumáticos/imunologia | pt_BR |
DeCS | Artrite Reumatoide/sangue | pt_BR |
DeCS | Artrite Reumatoide/imunologia | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Citometria de Fluxo | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Imunofenotipagem | pt_BR |
DeCS | Lúpus Eritematoso Sistêmico/sangue | pt_BR |
DeCS | Lúpus Eritematoso Sistêmico/imunologia | pt_BR |
DeCS | Meia-Idade | pt_BR |