| Author | Barros, Andréia Ferreira de | |
| Author | Oliveira, Sheilla Andrade de | |
| Author | Carvalho, Camila Lima | |
| Author | Silva, Fabiana Leticia | |
| Author | Souza, Veruska Cintia Alexandrino de | |
| Author | Silva, Anekecia Lauro da | |
| Author | Araújo, Roni Evencio de | |
| Author | Souza, Bruno Solano de Freitas | |
| Author | Soares, Milena Botelho Pereira | |
| Author | Costa, Vlaudia M. Assis | |
| Author | Coutinho, Eridan de Medeiros | |
| Access date | 2014-05-06T19:12:07Z | |
| Available date | 2014-05-06T19:12:07Z | |
| Document date | 2014 | |
| Citation | BARROS, Andréia Ferreira de et al. Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 1, p. 1-10, 2014. | pt_BR |
| ISSN | 0074-0276 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7587 | |
| Language | eng | pt_BR |
| Publisher | Fiocruz | pt_BR |
| Rights | open access | pt_BR |
| Title | Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/0074-0276140266 | |
| Abstract | Undernourished mice infected (UI) submitted to low and long-lasting infections by Schistosoma mansoni are unable to develop the hepatic periportal fibrosis that is equivalent to Symmers’ fibrosis in humans. In this report, the effects of the host’s nutritional status on parasite (worm load, egg viability and maturation) and host (growth curves, biology, collagen synthesis and characteristics of the immunological response) were studied and these are considered as interdependent factors influencing the amount and distribution of fibrous tissue in hepatic periovular granulomas and portal spaces. The nutritional status of the host influenced the low body weight and low parasite burden detected in UI mice as well as the number, viability and maturation of released eggs. The reduced oviposition and increased number of degenerated or dead eggs were associated with low protein synthesis detected in deficient hosts, which likely induced the observed decrease in transformation growth factor (TGF)-β1 and liver collagen. Despite the reduced number of mature eggs in UI mice, the activation of TGF-β1 and hepatic stellate cells occurred regardless of the unviability of most miracidia, due to stimulation by fibrogenic proteins and eggshell glycoproteins. However, changes in the repair mechanisms influenced by the nutritional status in deficient animals may account for the decreased liver collagen detected in the present study. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Medicina Tropical. Centro de Ciências da Saúde. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil / Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil / Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Medicina Tropical. Centro de Ciências da Saúde. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Subject | Schistosomiasis mansoni | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Undernutrition | pt_BR |
| Subject | Liver fibrosis | pt_BR |
