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AutorMiranda, Anderson Fontes Suzart
AutorSantos, Gustavo Miranda Pires
AutorOliveira, Susana Carla Pires Sampaio
AutorMonteiro, Juliana Santos de Carvalho
AutorSampaio, Fernando José Pires
AutorGomes Júnior, Rafael Araújo
AutorBrugnera Junior, Aldo
AutorGesteira, Maria de Fatima Malvar
AutorZanin, Fátima A. A
AutorPinheiro, Antonio Luiz Barbosa
AutorSantos, Marcos André Vannier dos
Fecha de acceso2014-05-09T17:40:17Z
Fecha de disponibilización2014-05-09T17:40:17Z
Fecha de publicación2014
ReferenciaMIRANDA, A. F. et al. Phenothiazinium dyes in association with diode red laser against. Progress in Biomedical Optics and Imaging Proceedings of SPIE, v. 893212, p. 1-6, 2014.pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/7597
Idiomaengpt_BR
EditorSPIEpt_BR
Derechos de autoropen accesspt_BR
TítuloPhenothiazinium dyes in association with diode red laser againstpt_BR
Tipo del documentoArticlept_BR
DOI10.1117/12.2038466
Resumen en InglésIn Brazil solar incidence is high and continuous throughout the year. Body exposure to sunlight may be a key point in the rates of individuals affected by melanoma and other types of skin cancer in many countries. Brazil already occupies the 15th place in the ranking of melanoma cases and the limitations presented by drugs used in the therapy of this cancer, new approaches are being used in an attempt to decrease the mortality of this malignancy. The aim of this study was to evaluate the effects of phenothiazinium dyes (PD) associated with laser light on murine melanoma (B16F10) in vitro by measuring cell growth using colorimetric assay before and after photodynamic therapy. We used a diode laser (λ660nm, 2.4 J/cm², 40 mW, 60 s, CW) associated with PD at 12.5 μg/mL, time pre-irradiation of 30 minutes). The following groups were tested: control (LF-), PD (L-F+), Laser (L+F-), Laser + PD (L+F+). The results showed a significant reduction in cell growth in the group treated by the photodynamic therapy compared to the control at 24 and 48 h (p < 0.001). Were showing at 30 min PD has a dose-dependent response on B16F10 cells, but at 24 h did not demonstrated this response.pt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biologia Parasitária. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biologia Parasitária. Salvador, BA, Brasilpt_BR
AfiliaciónCenter of Biophotonic. Federal University of Bahia. School of Dentistry. Salvador, BA, Brasil / National Institute of Optics and Photonics, São Carlos, SP, Brasilpt_BR
AfiliaciónCenter of Biophotonic. Federal University of Bahia. School of Dentistry. Salvador, BA, Brasil / National Institute of Optics and Photonics, São Carlos, SP, Brasil / Department of Biology. Estate University of Feira de Santana. Feira de Santana, BA, Brasilpt_BR
AfiliaciónCenter of Biophotonic. Federal University of Bahia. School of Dentistry. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biologia Parasitária. Salvador, BA, Brasilpt_BR
AfiliaciónCenter of Biophotonic. Federal University of Bahia. School of Dentistry. Salvador, BA, Brasil / National Institute of Optics and Photonics, São Carlos, SP, Brasil / Brugnera & Zanin Institute. São Paulo, SP, Brasilpt_BR
AfiliaciónCenter of Biophotonic. Federal University of Bahia. School of Dentistry. Salvador, BA, Brasilpt_BR
AfiliaciónCenter of Biophotonic. Federal University of Bahia. School of Dentistry. Salvador, BA, Brasil / National Institute of Optics and Photonics, São Carlos, SP, Brasil / Brugnera & Zanin Institute. São Paulo, SP, Brasilpt_BR
AfiliaciónCenter of Biophotonic. Federal University of Bahia. School of Dentistry. Salvador, BA, Brasil / National Institute of Optics and Photonics, São Carlos, SP, Brasil / Brugnera & Zanin Institute. São Paulo, SP, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biologia Parasitária. Salvador, BA, Brasilpt_BR
Palavras clave en InglêsLightpt_BR
Palavras clave en InglêsPDTpt_BR
Palavras clave en InglêsMelanomapt_BR
Palavras clave en InglêsLaserpt_BR


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