Author | Lima, Isadora dos Santos | |
Author | Silva, Joselli Santos | |
Author | Almeida, Valter dos Anjos | |
Author | Leal Junior, Floriano G | |
Author | Souza, Patrício A. N | |
Author | Larangeira, Daniela Farias | |
Author | Fraga, Deborah Bittencourt Mothé | |
Author | Freitas, Luiz Antonio Rodrigues de | |
Author | dosSantos, Washington Luis Conrado | |
Access date | 2014-05-23T13:30:54Z | |
Available date | 2014-05-23T13:30:54Z | |
Document date | 2014 | |
Citation | LIMA, I. S. et al. Severe clinical presentation of visceral leishmaniasis in naturally infected dogs with disruption of the splenic white pulp. Plos One, v. 9, p. e87742, 2014 | pt_BR |
ISSN | 1932-6203 | |
URI | https://www.arca.fiocruz.br/handle/icict/7644 | |
Language | eng | pt_BR |
Publisher | Royal Tropical Institute | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Tecido linfóide | pt_BR |
Subject in Portuguese | Leishmaniose visceral | pt_BR |
Subject in Portuguese | Leishmania | pt_BR |
Subject in Portuguese | Animais | pt_BR |
Subject in Portuguese | Cães | pt_BR |
Subject in Portuguese | Eutanasia animal | pt_BR |
Subject in Portuguese | Infecção | pt_BR |
Subject in Portuguese | Gravidade | pt_BR |
Title | Severe clinical presentation of visceral leishmaniasis in naturally infected dogs with disruption of the splenic white pulp. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0087742 | |
Abstract | In this work, we investigated the association between the disruption of splenic lymphoid tissue and the severity of visceral
leishmaniasis in dogs. Clinical and laboratory data from 206 dogs were reviewed. Spleen sections collected during the
euthanasia of these animals were analyzed, and the splenic lymphoid tissue samples were classified as well organized
(spleen type 1), slightly disorganized (spleen type 2), or moderately to extensively disorganized (spleen type 3). Of 199 dogs
with evidence of Leishmania infection, 54 (27%) had spleen type 1, 99 (50%) had spleen type 2, and 46 (23%) had spleen
type 3. The number of clinical signs associated with visceral leishmaniasis was significantly higher in the animals with
evidence of Leishmania infection and spleen type 2 or 3 than in the animals with spleen type 1. Alopecia, anemia,
dehydration, dermatitis, lymphadenopathy, and onychogryphosis were all more frequent among animals with evidence of
Leishmania infection and spleen type 3 than among the dogs with evidence of Leishmania infection and spleen type 1. The
association between the severity of canine visceral leishmaniasis and the disorganization of the splenic lymphoid tissue was
even more evident in the group of animals with positive spleen culture. Conjunctivitis and ulceration were also more
common in the animals with spleen type 3 than in the animals with spleen type 1. The serum levels (median, interquartile
range) of albumin (1.8, 1.4–2.3 g/dL) and creatinine (0.7, 0.4–0.8 mg/dL) were significantly lower and the serum levels of
aspartate aminotransferase were significantly higher (57, 39–95 U) in animals with spleen type 3 than in animals with spleen
type 1 (2.8, 2.4–3.4 g/dL; 0.9, 0.7–1.2 mg/dL and 23, 20–32 U, respectively). Our data confirm the hypothesis that disruption
of the splenic lymphoid tissue is associated with a more severe clinical presentation of canine visceral leishmaniasis. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Centro de Referência em Doenças Endêmicas Pirajá da Silva (PIEJ). Jequié, BA, Brasil | pt_BR |
Affilliation | Centro de Referência em Doenças Endêmicas Pirajá da Silva (PIEJ). Jequié, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Escola de Medicina Veterinária. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Amazônia. Faculdade de Ciências Farmacêuticas. Manaus, AM, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Medicina Veterinária. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |