Author | Miguel, Fúlvio Borges | |
Author | Barbosa Junior, Aryon de Almeida | |
Author | Paula, Fabiana Lopes de | |
Author | Barreto, Isabela Cerqueira | |
Author | Goissis, Gilberto | |
Author | Rosa, Fabiana Paim | |
Access date | 2014-06-04T19:41:27Z | |
Available date | 2014-06-04T19:41:27Z | |
Document date | 2013 | |
Citation | MIGUEL, F. B. et al. Regeneration of critical bone defects with anionic collagen matrix as scaffolds. Journal of Materials Science: Materials in Medicine, v. 24, n. 11, p. 2567-275, 2013. | pt_BR |
ISSN | 1573-4838 | |
URI | https://www.arca.fiocruz.br/handle/icict/7796 | |
Language | eng | pt_BR |
Publisher | Springer Verlag | pt_BR |
Rights | open access | pt_BR |
Title | Regeneration of critical bone defects with anionic collagen matrix as scaffolds. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1007/s10856-013-4980-8 | |
Abstract | The aim of this study was to make a histomorphometric evaluation of the osteogenic potential of anionic collagen matrix as scaffolds; either crosslinked in glutaraldehyde or not cross-linked and, implanted in critical bone defects in rat calvaria. Seventy-two rats were randomly distributed in three groups: anionic collagen scaffolds treated for 24 h of selective hydrolysis (ACSH); anionic collagen scaffolds treated for 24 h of selective hydrolysis and 5 min of crosslinking in glutaraldehyde 0.05% (ACSHGA); empty bone defect (Control), evaluated at the biological points of 15, 45, 90 and 120 days. The results showed that the biomaterials implanted were biocompatible and showed a high osteogenic potential. These biomaterials presented a speed of biodegradation compatible with bone neoformation, which was shown to be associated with angiogenesis inside the scaffolds at all biological points. The percentage of mineralization of ACSH (87%) differed statistically from that found in ACSHGA (66%). It was concluded that the regeneration of critical bone defect was more evident in anionic collagen without crosslinking (ACSH). | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Health Sciences Center of Federal University of the Recôncavo of Bahia. Santo Antônio de Jesus, BA, Brasil | pt_BR |
Affilliation | Health Sciences Institute of Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Biotech Biomédica. São Carlos, SP, Brasil | pt_BR |
Affilliation | Health Sciences Institute of Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
DeCS | Colágeno | pt_BR |
DeCS | Ossos | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Ratos | pt_BR |
DeCS | Implante | pt_BR |
DeCS | Biomateriais | pt_BR |