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AutorPearson, Mark S.
AutorTribolet, Leon
AutorCantacessi, Cinzia
AutorPeriago, Maria Victoria
AutorValerio, Maria Adela
AutorJariwala, Amar R.
AutorHotez, Peter J.
AutorDiemert, David J.
AutorLoukas, Alex
AutorBethony, Jeffrey Michael
Fecha de acceso2014-06-17T13:31:15Z
Fecha de disponibilización2014-06-17T13:31:15Z
Fecha de publicación2012
ReferenciaPEARSON, Mark S. et al. Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines. Journal of Allergy and Clinical Immunology. 2012, vol.130, pp. 13-21pt_BR
ISSN0091-6749
URIhttps://www.arca.fiocruz.br/handle/icict/7824
Idiomaengpt_BR
EditorElsevierpt_BR
Derechos de autoropen accesspt_BR
TítuloMolecular mechanisms of hookworm disease: Stealth, virulence, and vaccinespt_BR
Tipo del documentoArticlept_BR
Resumen en InglésHookworms produce a vast repertoire of structurally and functionally diverse molecules that mediate their long-term survival and pathogenesis within a human host. Many of these molecules are secreted by the parasite, after which they interact with critical components of host biology, including processes that are key to host survival. The most important of these interactions is the hookworm’s interruption of nutrient acquisition by the host through its ingestion and digestion of host blood. This results in iron deficiency and eventually the microcytic hypochromic anemia or iron deficiency anemia that is the clinical hallmark of hookworm infection. Other molecular mechanisms of hookworm infection cause a systematic suppression of the host immune response to both the parasite and to bystander antigens (eg, vaccines or allergens). This is achieved by a series of molecules that assist the parasite in the stealthy evasion of the host immune response. This review will summarize the current knowledge of the molecular mechanisms used by hookworms to survive for extended periods in the human host (up to 7 years or longer) and examine the pivotal contributions of these molecular mechanisms to chronic hookworm parasitism and host clinical outcomes.pt_BR
AfiliaciónJames Cook University. Center for Biodiscovery and Molecular Development of Therapeutics. Cairns, USApt_BR
AfiliaciónJames Cook University. Center for Biodiscovery and Molecular Development of Therapeutics. Cairns, USApt_BR
AfiliaciónJames Cook University. Center for Biodiscovery and Molecular Development of Therapeutics. Cairns, USApt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasilpt_BR
AfiliaciónUniversidad de Valencia. Departamento de Parasitologıa. Valencia, Espanhapt_BR
AfiliaciónGeorge Washington University.Department of Microbiology, Immunology and Tropical Medicine. Washington, USApt_BR
AfiliaciónNational School of Tropical Medicine. Baylor College of Medicine, Department of Pediatrics and Molecular Virology and Microbiology. Houston, USA/Sabin Vaccine Institute. Texas Children’s Hospital. Center for Vaccine Development, Houston, USApt_BR
AfiliaciónGeorge Washington University.Department of Microbiology, Immunology and Tropical Medicine. Washington, USApt_BR
AfiliaciónJames Cook University. Center for Biodiscovery and Molecular Development of Therapeutics. Cairns, USApt_BR
AfiliaciónGeorge Washington University.Department of Microbiology, Immunology and Tropical Medicine. Washington, USApt_BR
Palavras clave en InglêsHookwormspt_BR
Palavras clave en Inglêsvirulence factorspt_BR
Palavras clave en Inglêsimmune modulationpt_BR
Palavras clave en Inglêsvaccinespt_BR
Palavras clave en Inglêsproteasespt_BR
Palavras clave en InglêsAncylostoma secreted proteinspt_BR
xmlui.metadata.dc.subject.ods03 Saúde e Bem-Estar


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