| Author | Maciel, Marcia Cristina Gonçalves | |
| Author | Fialho, Eder Magalhães Silva | |
| Author | Guerra, Rosane Nassar Meireles | |
| Author | Borges, Valeria de Matos | |
| Author | Kwasniewski, Fabio Henrique | |
| Author | Nascimento, Flávia Raquel Fernandes do | |
| Access date | 2014-07-07T17:28:35Z | |
| Available date | 2014-07-07T17:28:35Z | |
| Document date | 2014 | |
| Citation | MACIEL, M. C. et al. Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice. Toxicon, p. 1-8, 2014. | pt_BR |
| ISSN | 0041-0101 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7874 | |
| Language | eng | pt_BR |
| Publisher | Elsevier Ltd | pt_BR |
| Rights | open access | pt_BR |
| Title | Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.toxicon.2014.06.018 | |
| Abstract | Tityus serrulatus venom (Tsv) modifies the behavior of immune cells and induces the
production of inflammatory and anti-inflammatory cytokines; such action may interfere
with physiological or pathological states. Because sepsis is characterized as an inflammatory
disorder, the aim of present study was to investigate the effect of a non-lethal dose
of Tsv in mice submitted to a polymicrobial infection by cecal ligation and puncture (CLP)
model. The parameters evaluated were survival index, cellularity on lymphoid organs,
peritoneal cavity and brochoalveolar space, production of IL-10, IL-12, IL-6, TNF-a, IFN-g
and MCP-1, pulmonary inflammation and oxidative burst. The results demonstrated that in
sharp contrast to CLP group in which sepsis was lethal in a 24 h period all mice pretreated
with Tsv survived even 60 h after CLP. Lung inflammation, another hallmark of CLP group,
was also dramatically down regulated in Tsv/CLP group. Despite pretreatment with Tsv did
not reduce the inflammatory serum cytokines when compared to CLP group; there was an
increase in IL-10. In conclusion, subcutaneous Tsv administration 6 h before CLP was able
to control the harmful effects of sepsis (lethality and lung inflammation). We suggest that
both systemic IL-10 and oxidative burst are involved in this effect | pt_BR |
| Affilliation | Universidade Federal do Maranhão. Laboratorio de Imunofisiologia. Departamento de Patologia. Centro de Ciências Biologicas e da Saúde. São Luís, MA, Brasil | pt_BR |
| Affilliation | Universidade Federal do Maranhão. Laboratorio de Imunofisiologia. Departamento de Patologia. Centro de Ciências Biologicas e da Saúde. São Luís, MA, Brasil | pt_BR |
| Affilliation | Universidade Federal do Maranhão. Laboratorio de Imunofisiologia. Departamento de Patologia. Centro de Ciências Biologicas e da Saúde. São Luís, MA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Estadual de Londrina. Laborat orio de Imunofarmacologia. Departamento de Ciências Patol ogicas. Centro de Ciências Biol ogicas. Londrina, PR, Brasil | pt_BR |
| Affilliation | Universidade Federal do Maranhão. Laboratorio de Imunofisiologia. Departamento de Patologia. Centro de Ciências Biologicas e da Saúde. São Luís, MA, Brasil | pt_BR |
| Subject | Tityus serrulatus | pt_BR |
| Subject | Venom | pt_BR |
| Subject | CLP | pt_BR |
| Subject | Sepsis | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | Cytokines | pt_BR |
