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| Autor | Freitas, Luiz Antonio Rodrigues de | |
| Autor | Mbow, M. Lamine | |
| Autor | Estay, Monica | |
| Autor | Bleyenberg, Julie A | |
| Autor | Titus, Richard G | |
| Fecha de acceso | 2014-07-10T12:30:06Z | |
| Fecha de disponibilización | 2014-07-10T12:30:06Z | |
| Fecha de publicación | 1999 | |
| Referencia | FREITAS, L. A. R. et al. Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major. Parasite Immunology, v. 21, n. 5, p. 273-277, 1999. | pt_BR |
| ISSN | 0141-9838 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7900 | |
| Idioma | eng | pt_BR |
| Editor | Blackwell Science | pt_BR |
| Derechos de autor | open access | pt_BR |
| Título | Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major. | pt_BR |
| Tipo del documento | Article | pt_BR |
| Resumen en Inglés | Prostaglandins of the E series inhibit the development of Th1 responses. When infected with Leishmania major, BALB/c mice fail to develop a Th1 response, but instead mount a Th2 response and die of the disease. Therefore, we treated L. major-infected BALB/c mice with indomethacin, which inhibits prostaglandin production. Indomethacin lessened disease severity (parasite burden and pathology), and promoted a Th1 response, but the mice still succumbed to infection. The explanation for these observations may be two-fold: (1) the beneficial effects of indomethacin were predominantly observed later in infection (beyond two weeks), a time at which indomethacin was unable to sufficiently block the development of a Th2 response; (2) indomethacin was unable to induce a Th1 response in BALB/c mice that was of the same magnitude as the Th1 response observed in C57BL/6 mice infected with L. major. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Celular. Salvador, BA, Brasil | pt_BR |
| Afiliación | Colorado State University. Department of Pathology. College of Veterinary Medicine and Biomedical Sciences. Fort Collins, USA | pt_BR |
| Afiliación | Colorado State University. Department of Pathology. College of Veterinary Medicine and Biomedical Sciences. Fort Collins, USA | pt_BR |
| Afiliación | Colorado State University. Department of Pathology. College of Veterinary Medicine and Biomedical Sciences. Fort Collins, USA | pt_BR |
| Afiliación | Colorado State University. Department of Pathology. College of Veterinary Medicine and Biomedical Sciences. Fort Collins, USA | pt_BR |
| Palavras clave en Inglês | Leishmania major | pt_BR |
| Palavras clave en Inglês | Leishmaniasis | pt_BR |
| Palavras clave en Inglês | Prostaglandins | pt_BR |
| Palavras clave en Inglês | Cytokines | pt_BR |
| Palavras clave en Inglês | Nitric oxide | pt_BR |
| DeCS | Antiprotozoários/uso terapêutico | pt_BR |
| DeCS | Indometacina/uso terapêutico | pt_BR |
| DeCS | Leishmania major | pt_BR |
| DeCS | Leishmaniose Cutânea/quimioterapia | pt_BR |
| DeCS | Células Th1/imunologia | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Inibidores de Ciclo-Oxigenase/uso terapêutico | pt_BR |
| DeCS | Progressão da Doença | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Imunidade Celular | pt_BR |
| DeCS | Leishmaniose Cutânea/imunologia | pt_BR |
| DeCS | Camundongos | pt_BR |
| DeCS | Camundongos Endogâmicos BALB C | pt_BR |
| DeCS | Antagonistas de Prostaglandina/uso terapêutico | pt_BR |
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