| Author | Mendonça, Vitor Rosa Ramos de | |
| Author | Luz, Nívea Farias | |
| Author | Santos, Nadja de Jesus Gonçalves dos | |
| Author | Borges, Valeria de Matos | |
| Author | Gonçalves, Marilda de Souza | |
| Author | Andrade, Bruno de Bezerril | |
| Author | Barral Netto, Manoel | |
| Access date | 2014-07-14T12:34:54Z | |
| Available date | 2014-07-14T12:34:54Z | |
| Document date | 2012 | |
| Citation | MENDONÇA, V. R. R. et al. Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria. Infection and Immunity, v. 80, n. 4, p. 1445-1154, 2012. | pt_BR |
| ISSN | 1098-5522 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7939 | |
| Language | eng | pt_BR |
| Publisher | American Society for Microbiology | pt_BR |
| Rights | open access | pt_BR |
| Title | Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1128/IAI.05933-11 | |
| Abstract | Intravascular hemolysis is a hallmark event in the immunopathology of malaria that results in increased systemic concentrations
of free hemoglobin (Hb). The oxidation of Hb by free radicals causes the release of heme, which amplifies inflammation. To
circumvent the detrimental effects of free heme, hosts have developed several homeostatic mechanisms, including the enzyme
haptoglobin (Hp), which scavenges cell-free Hb, the monocyte receptor CD163, which binds to Hb-Hp complexes, and heme
oxygenase-1 (HO-1), which degrades intracellular free heme. We tested the association between these three main components of
the host response to hemolysis and susceptibility to malaria in a Brazilian population. The genetic profiles of the HMOX1 and
Hp genes and the plasma levels of a serum inflammatory marker, the soluble form of the CD163 receptor (sCD163), were studied
in 264 subjects, including 78 individuals with symptomatic malaria, 106 individuals with asymptomatic malaria, and 80 uninfected
individuals. We found that long (GT)n repeats in the microsatellite polymorphism region of the HMOX1 gene, the Hp2
allele, and the Hp2.2 genotype were associated with symptomatic malaria. Moreover, increased plasma concentrations of heme,
Hp, HO-1, and sCD163 were associated with susceptibility to malaria. The validation of these results could support the development
of targeted therapies and aid in reducing the severity of malaria | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia (iii-INCT). São Paulo, SP, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil | pt_BR |
| Affilliation | National Institute of Allergy and Infectious Diseases. National Institutes of Health. Immunobiology Section. Laboratory of Parasitic Diseases. Bethesda, Maryland, USAe | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia (iii-INCT). São Paulo, SP, Brasil | pt_BR |
| DeCS | Antígenos CD/sangue | pt_BR |
| DeCS | Antígenos de Diferenciação Mielomonocítica/sangue | pt_BR |
| DeCS | Haptoglobinas/genética | pt_BR |
| DeCS | Heme Oxigenase-1/genética | pt_BR |
| DeCS | Malária/genética | pt_BR |
| DeCS | Malária/imunologia | pt_BR |
| DeCS | Receptores de Superfície Celular/sangue | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Alelos | pt_BR |
| DeCS | Brasil | pt_BR |
| DeCS | Suscetibilidade a Doenças | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Haptoglobinas/metabolismo | pt_BR |
| DeCS | Heme/metabolismo | pt_BR |
| DeCS | Heme Oxigenase-1/metabolismo | pt_BR |
| DeCS | Hemoglobinas/metabolismo | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Repetições de Microssatélites | pt_BR |
| DeCS | Meia-Idade | pt_BR |
| DeCS | Polimorfismo Genético | pt_BR |
