Author | Cerqueira, Bruno Antonio Veloso | |
Author | Santos, Wendell Vilas Boas | |
Author | Zanette, Angela Maria Dias | |
Author | Reis, Mitermayer Galvão dos | |
Author | Gonçalves, Marilda de Souza | |
Access date | 2014-07-14T13:56:39Z | |
Available date | 2014-07-14T13:56:39Z | |
Document date | 2011 | |
Citation | CERQUEIRA, B. A. V. et al. Increased concentrations of IL-18 and uric acid in sickle cell anemia: contribution of hemolysis, endothelial activation and the inflammasome. Cytokine, v. 56, n. 2, p. 471-476, 2011. | pt_BR |
ISSN | 1096-0023 | |
URI | https://www.arca.fiocruz.br/handle/icict/7946 | |
Language | eng | pt_BR |
Publisher | Elsevier Ltd | pt_BR |
Rights | open access | pt_BR |
Title | Increased concentrations of IL-18 and uric acid in sickle cell anemia: contribution of hemolysis, endothelial activation and the inflammasome. | pt_BR |
Type | Article | pt_BR |
DOI | :10.1016/j.cyto.2011.08.013 | |
Abstract | Sickle cell anemia (SCA) is a common, severe monogenetic disorder characterized by chronic hemolysis,
frequent infections, a chronic inflammatory state and recurrent occlusions of the microcirculation, resulting
in painful crises, organ damage and premature death. This study evaluated associations between
serum levels of IL-18, uric acid, hemolytic markers, and inflammatory molecules in SCA patients. A
cross-sectional study was performed including 45 SCA patients (median age of 20.5 years) without general
symptoms and who had not undergone blood transfusions. Inclusion criteria for the steady-state SCA
patients were the absence of hospitalization and the absence of infections. Interleukin-18 and uric acid
levels were correlated closely with markers of hemolysis, endothelial dysfunction and others cytokines
levels. These findings suggest probable influences of IL-18 and uric acid in the pathophysiology of vascular
occlusion in SCA. Additional studies should be performed to characterize similar prognosis markers
and possible therapeutic targets. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia (UFBA). Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil | pt_BR |
Subject | Sickle cell anemia | pt_BR |
Subject | Cytokine | pt_BR |
Subject | Inflammation | pt_BR |
DeCS | Anemia Falciforme/sangue | pt_BR |
DeCS | Endotélio Vascular/metabolismo | pt_BR |
DeCS | Hemólise | pt_BR |
DeCS | Inflamassomos/metabolismo | pt_BR |
DeCS | Interleucina-18/sangue | pt_BR |
DeCS | Ácido Úrico/sangue | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Moléculas de Adesão Celular/metabolismo | pt_BR |
DeCS | Estudos Transversais | pt_BR |
DeCS | Endotélio Vascular/patologia | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Masculino | pt_BR |