| Author | Gomes, Juliana de Assis Silva | |
| Author | Araújo, Fernanda Fortes de | |
| Author | Trindade, Giliane de Souza | |
| Author | Quinan, Bárbara Resende | |
| Author | Drumond, Betânia Paiva | |
| Author | Ferreira, Jaqueline Maria Siqueira | |
| Author | Mota, Bruno Eduardo Fernandes | |
| Author | Nogueira, Maurício Lacerda | |
| Author | Kroon, Erna Geessien | |
| Author | Abrahão, Jônatas Santos | |
| Author | Oliveira, Rodrigo Corrêa de | |
| Author | Fonseca, Flávio Guimarães da | |
| Access date | 2014-07-14T18:55:13Z | |
| Available date | 2014-07-14T18:55:13Z | |
| Document date | 2012 | |
| Citation | GOMES, Juliana Assis Silva et al. Immune modulation in primary vaccinia virus zoonotic human infections. Clinical and Developmental Immunology. 2012; vol.2012, pp. 974067. | pt_BR |
| ISSN | 1740-2522 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7954 | |
| Sponsorship | FAPEMIG , CNPq, National Institute of Science and Technology in Vaccines | pt_BR |
| Language | eng | pt_BR |
| Publisher | Hindawi Publishing Corporation | pt_BR |
| Rights | open access | pt_BR |
| Title | Immune modulation in primary vaccinia virus zoonotic human infections | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1155/2012/974067 | |
| Abstract | In 2010, the WHO celebrated the 30th anniversary of the smallpox eradication. Ironically, infections caused by viruses related to smallpox are being increasingly reported worldwide, including Monkeypox, Cowpox, and Vaccinia virus (VACV). Little is known about the human immunological responses elicited during acute infections caused by orthopoxviruses. We have followed VACV zoonotic outbreaks taking place in Brazil and analyzed cellular immune responses in patients acutely infected by VACV. Results indicated that these patients show a biased immune modulation when compared to noninfected controls. Amounts of B cells are low and less activated in infected patients. Although present, T CD4+ cells are also less activated when compared to noninfected individuals, and so are monocytes/macrophages. Similar results were obtained when Balb/C mice were experimentally infected with a VACV sample isolated during the zoonotic outbreaks. Taking together, the data suggest that zoonotic VACVs modulate specific immune cell compartments during an acute infection in humans | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Faculdade de Medicina de São José do Rio Preto. Departamento de Doenças Infecciosas e Parasitárias. São José do Rio Preto, SP, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | CD4-Positive T-Lymphocytes | pt_BR |
| Subject | Antigens | pt_BR |
| Subject | Immunity, Cellular | pt_BR |
| Subject | Lymphocyte Activation | pt_BR |
