| Author | Trindade, Bruno Caetano | |
| Author | Faccioli, Lúcia Helena | |
| Author | Martins Filho, Olindo Assis | |
| Author | Nicolete, Larissa Deadame de Figueiredo | |
| Author | Malta, Tathiane Maistro | |
| Author | Pinto, Mariana Tomazini | |
| Author | Kashima, Simone Haddad | |
| Author | Takayanagui, Osvaldo Massaiti | |
| Author | Covas, Dimas Tadeu | |
| Author | Sorgi, Carlos Artério | pt_BR |
| Access date | 2014-07-17T18:44:36Z | |
| Available date | 2014-07-17T18:44:36Z | |
| Document date | 2012 | |
| Citation | TRINDADE, Bruno Caetano et al. Leukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory disease. Plos One. 2012, vol.7, pp. e51873 | pt_BR |
| ISSN | 1932-6203 | |
| ISSN | 10.1371/journal.pone.0051873 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7990 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Title | Leukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory disease | pt_BR |
| Type | Article | pt_BR |
| Abstract | Leukotrienes (LTs) are lipid mediators involved in several inflammatory disorders. We investigated the LT pathway in human T-lymphotropic virus type 1 (HTLV-1) infection by evaluating LT levels in HTLV-1-infected patients classified according to the clinical status as asymptomatic carriers (HACs) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. Bioactive LTB4 and CysLTs were both increased in the plasma and in the supernatant of peripheral blood mononuclear cell cultures of HTLV-1-infected when compared to non-infected. Interestingly, CysLT concentrations were increased in HAM/TSP patients. Also, the concentration of plasma LTB4 and LTC4 positively correlated with the HTLV-1 proviral load in HTLV-1-infected individuals. The gene expression levels of LT receptors were differentially modulated in CD4+ and CD8+ T cells of HTLV-1-infected patients. Analysis of the overall plasma signature of immune mediators demonstrated that LT and chemokine amounts were elevated during HTLV-1 infection. Importantly, in addition to CysLTs, IP-10 was also identified as a biomarker for HAM/TSP activity. These data suggest that LTs are likely to be associated with HTLV-1 infection and HAM/TSP development, suggesting their putative use for clinical monitoring. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Laboratório de Inflamação e Imunologia das Parasitoses. Ribeirão Preto, SP, Brazil/Fundação Oswaldo Cruz Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Laboratório de Inflamação e Imunologia das Parasitoses. Ribeirão Preto, SP, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Instituto Nacional de Ciência e Tecnologia em Células-Tronco e Terapia Celular/Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, Brazil | pt_BR |
| Affilliation | Instituto Nacional de Ciência e Tecnologia em Células-Tronco e Terapia Celular/Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, Brazil | pt_BR |
| Affilliation | Instituto Nacional de Ciência e Tecnologia em Células-Tronco e Terapia Celular/Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, Brazil | pt_BR |
| Affilliation | Instituto Nacional de Ciência e Tecnologia em Células-Tronco e Terapia Celular/Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, Brazil | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Neurociências e Ciências do Comportamento. Ribeirão Preto, SP, Brazil | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica. Ribeirão Preto, SP, Brazil/ Instituto Nacional de Ciência e Tecnologia em Células-Tronco e Terapia Celular/Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, Brazil | pt_BR |
| Subject | inflammatory disorders | pt_BR |
| Subject | Leukotrienes | pt_BR |
