| Author | Alcantara, Luiz Carlos Júnior | |
| Author | Van Dooren, Sonia | |
| Author | Gonçalves, Marilda de Souza | |
| Author | Kashima, Simone G | |
| Author | Costa, Maria Cristina Ramos | |
| Author | Santos, Fred Luciano Neves | |
| Author | Bittencourt, Achilea Candida Lisboa | |
| Author | Dourado, Inês | |
| Author | Andrade Filho, Antonio de Souza | |
| Author | Covas, Dimas Tadeu | |
| Author | Vandamme, Anne-Mieke | |
| Author | Castro Filho, Bernardo Galvão | |
| Access date | 2014-07-17T19:33:23Z | |
| Available date | 2014-07-17T19:33:23Z | |
| Document date | 2003 | |
| Citation | ALCANTARA JUNIOR, L. C. et al. Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus. Journal of Acquired Immune Deficiency Syndromes, v. 33, n. 4, p. 536-542, 2003. | pt_BR |
| ISSN | 1525-4135 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7994 | |
| Language | eng | pt_BR |
| Publisher | Mary Ann Liebert, Inc | pt_BR |
| Rights | open access | pt_BR |
| Title | Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus. | pt_BR |
| Type | Article | pt_BR |
| Abstract | The city of Salvador, Bahia, Brazil, has sociodemographic characteristics
similar to some African cities. Up to now, it has had the highest prevalence of human
T-cell lymphotropic virus type I (HTLV-I) infection (1.74%) in the country. To investigate
which strains of HTLV-I are circulating in Salvador, we studied isolates from
82 patients infected with HTLV-I: 19 from the general population, 21 from pregnant
women, 16 from intravenous drug users, and 26 from patients and their family attending
a neurologic clinic. Phylogenetic analysis from part of the LTR fragments showed
that most of these isolates belonged to the Transcontinental subgroup of the Cosmopolitan
subtype (HTLV-Ia). Only one sample from a pregnant woman was closely
related to the Japanese subgroup, suggesting recent introduction of a Japanese HTLV-I
lineage into Salvador. A-Globin haplotypes were examined in 34 infected individuals
and found to be atypical, confirming the racial heterogeneity of this population. A total
of 20 chromosomes were characterized as Central African Republic (CAR) haplotype
(29.4%), 31 (45.6%) were characterized as Benin (BEN) haplotype, and 17 (25%) were
characterized as Senegal (SEN) haplotype. Five patients’ genotypes (14.7%) were
CAR/CAR; 10 (29,4%), BEN/BEN; 9 (26.5%), CAR/BEN; 2 (5.9%), BEN/SEN; and
7 (20.6%), SEN/SEN. One patient’s genotype (2.9%) was CAR/SEN. The A-globin
haplotype distribution in Salvador is unusual compared with other Brazilian states. Our
data support the hypothesis of multiple post-Columbian introductions of African
HTLV-Ia strains in Salvador, Bahia, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Foundation for Scientific Development. Salvador, BA, Brasil | pt_BR |
| Affilliation | Rega Institute. Katholieke Universiteit Leuven. Belgium | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Brazil Blood Scientific Development. Salvador, BA, Brasil | pt_BR |
| Affilliation | Brazil Blood Scientific Development. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Foundation for Scientific Development. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Bahia School of Medicine and Public Health. Foundation for Scientific Development. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Brazil Blood Scientific Development. Salvador, BA, Brasil | pt_BR |
| Affilliation | Rega Institute. Katholieke Universiteit Leuven. Belgium | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Foundation for Scientific Development. Salvador, BA, Brasil | pt_BR |
| Subject | HTLV-1 | pt_BR |
| Subject | LTR | pt_BR |
| Subject | B globin haplotypes | pt_BR |
| Subject | Bantu | pt_BR |
| Subject | Salvador-Brazil | pt_BR |
| Subject | Southern Africa | pt_BR |
| DeCS | Globinas/genética | pt_BR |
| DeCS | Infecções por HTLV-I/virologia | pt_BR |
| DeCS | Haplotipos | pt_BR |
| DeCS | Vírus 1 Linfotrópico T Humano/classificação | pt_BR |
| DeCS | Brasil | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Filogenia | pt_BR |
| DeCS | Sequências Repetidas Terminais | pt_BR |
