| Author | Mota, Augusto César de Andrade | |
| Author | Van Dooren, Sonia | |
| Author | Fernandes, Flora Maria de Campos | |
| Author | Pereira, Sergio Araujo | |
| Author | Queiroz, Artur Trancoso Lopo de | |
| Author | Gallazzi, Viviana Nilla Olavarria | |
| Author | Vandamme, Anne-Mieke | |
| Author | Castro Filho, Bernardo Galvão | |
| Author | Alcantara, Luiz Carlos Júnior | |
| Access date | 2014-07-30T19:34:49Z | |
| Available date | 2014-07-30T19:34:49Z | |
| Document date | 2007 | |
| Citation | MOTA, A. C. A. et al. The close relationship between South African and Latin American HTLV type 1 strains corroborated in a molecular epidemiological study of the HTLV type 1 isolates from a blood donor cohort. AIDS Research and Human Retroviruses, v. 23, n. 4, p. 503-507, 2007. | pt_BR |
| ISSN | 0889-2229 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8100 | |
| Language | eng | pt_BR |
| Publisher | Mary Ann Liebert, Inc | pt_BR |
| Rights | restricted access | pt_BR |
| Title | The close relationship between South African and Latin American HTLV type 1 strains corroborated in a molecular epidemiological study of the HTLV type 1 isolates from a blood donor cohort. | pt_BR |
| Type | Article | |
| DOI | 10.1089/aid.2006.0203 | |
| Abstract | It has been difficult to explain why all HTLV-1 sequences in Salvador, a city in the northeast of Brazil, belong
to the Transcontinental (A) subgroup of the Cosmopolitan (a) subtype, since according to historical data
the vast majority of slaves brought to Brazil (through Salvador) came from west Africa, where only the western
African subgroup (C) has been found. To shed more light on this subject we conducted a phylogenetic
analysis of 23 isolates from blood donors of Salvador. DNA was extracted and submitted to a nested PCR for
amplification of the entire LTR region. The PCR products were purified and sequenced on an automated sequencer.
Neighbor-joining and maximum likelihood phylogenetic analyses were performed. None of the new
sequences from Salvador clustered within the West-African subgroup C. Confirming previous results, all sequences
belonged to the Transcontinental subgroup (A) of the Cosmopolitan subtype, and clustered in two
Latin American clusters. In addition we showed sequences from southern Africa clustering in both Latin
American clusters. One of the new sequences is ancestral to the larger Latin American cluster beta due to a
duplication of a 12-bp long fragment, a finding that has not been previously described. These findings support
the hypothesis that HTLV-1 isolates circulating in Latin America have a closer relationship to South
African compared to West-African HTLV-1 strains. The 12-bp-long duplications in one of the sequences has
no obvious clinical or biological implications yet. | pt_BR |
| Affilliation | Bahia School of Medicine and Public Health. Salvador, BA, Brasil / Foundation for Scientific Development. Salvador, BA, Brasil | pt_BR |
| Affilliation | Rega Institute for Medical Research. Katholieke Universiteit Leuven. Leven, Belgium | pt_BR |
| Affilliation | Bahia School of Medicine and Public Health. Salvador, BA, Brasil / Foundation for Scientific Development. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Bahia School of Medicine and Public Health. Salvador, BA, Brasil / Foundation for Scientific Development. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Rega Institute for Medical Research. Katholieke Universiteit Leuven. Leven, Belgium | pt_BR |
| Affilliation | Bahia School of Medicine and Public Health. Salvador, BA, Brasil / Foundation for Scientific Development. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Bahia School of Medicine and Public Health. Salvador, BA, Brasil / Foundation for Scientific Development. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
| DeCS | Doadores de Sangue | pt_BR |
| DeCS | Infecções por HTLV-I/etnologia | pt_BR |
| DeCS | Infecções por HTLV-I/epidemiologia | pt_BR |
| DeCS | Vírus 1 Linfotrópico T Humano/classificação | pt_BR |
| DeCS | Brasil/epidemiologia | pt_BR |
| DeCS | Estudos de Coortes | pt_BR |
| DeCS | Infecções por HTLV-I/genética | pt_BR |
| DeCS | Vírus 1 Linfotrópico T Humano/genética | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Oriente Médio/epidemiologia | pt_BR |
| DeCS | Dados de Sequência Molecular | pt_BR |
| DeCS | Filogenia | pt_BR |
