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| Autor | Guimarães, Monick Lindenmeyer | |
| Autor | Moreira, Aline dos Santos | |
| Autor | Loureiro, Regina | |
| Autor | Castro Filho, Bernardo Galvão | |
| Autor | Morgado, Mariza Gonçalves | |
| Fecha de acceso | 2014-08-06T14:08:08Z | |
| Fecha de disponibilización | 2014-08-06T14:08:08Z | |
| Fecha de publicación | 2002 | |
| Referencia | GUIMARÃES, L. M. et al. High frequency of recombinant genomes in HIV type 1 samples from Brazilian southeastern and southern regions. AIDS Research and Human Retroviruses, v. 18, n. 17, p. 1261-1269, 2002. | pt_BR |
| ISSN | 0889-2229 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8138 | |
| Idioma | eng | pt_BR |
| Editor | Mary Ann Liebert, Inc | pt_BR |
| Derechos de autor | open access | pt_BR |
| Título | High frequency of recombinant genomes in HIV type 1 samples from Brazilian southeastern and southern regions. | pt_BR |
| Tipo del documento | Article | pt_BR |
| Resumen en Inglés | We describe the genetic variability of HIV-1 subtypes and recombinant genomes in samples from southeastern and southern Brazilian regions. Phylogenetic analysis of a subset of 34 samples (8F, 7B, 7C, 2D, 1A, and 9 B0 variant) based on the DNA sequencing of the env gp120 and gp41, gag p17, and nef regions confirmed the presence of nine (26.5%) potentially HIV-1 recombinant genomes. From the eight C2–V3 gp120 subtype F samples, only two seem to be pure F. One of the samples, classified as B0 in the C2–V3 gp120 and as B in gp41 had the gag and nef regions clustering with subtype C. Two of seven C2–V3 subtype C samples presented distinct recombinant patterns as Bgag/Cenv/Bnef and Bgag/Cenv/Cnef. Putative recombinant breakpoints were obtained for three samples presenting discordant subtypes (F/B) between gp120 and gp41 env fragments showing that similar breakpoints could be observed between two unlinked samples (95BRRJ014 and 96BRRJ101). A higher degree of polymorphism was verified in the analysis of a subtype A sample (98BRRS058) in the C2–V3/gp41 env fragment. The intrasubtype C distance was found to be lower than that found for the other subtypes for all genomic regions. These data confirm that distinct HIV-1 subtypes and recombinant forms are actively participating in the Brazilian AIDS epidemic, and that the subtype C was introduced more recently into southern Brazil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, Brasil | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, Brasil | pt_BR |
| Afiliación | Public Healthy Secretariat of RS State. Porto Alegre, RS, Brasil | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, Brasil | pt_BR |
| DeCS | Genoma Viral | pt_BR |
| DeCS | HIV-1/classificação | pt_BR |
| DeCS | HIV-1/genética | pt_BR |
| DeCS | Recombinação Genética | pt_BR |
| DeCS | Sequência de Bases | pt_BR |
| DeCS | Brasil | pt_BR |
| DeCS | Frequência do Gene | pt_BR |
| DeCS | Proteína gp120 do Envelope de HIV/genética | pt_BR |
| DeCS | Proteína gp41 do Envelope de HIV/genética | pt_BR |
| DeCS | Dados de Sequência Molecular | pt_BR |
| DeCS | Filogenia | pt_BR |
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