| Autor | Guimarães, Monick Lindenmeyer | |
| Autor | Bastos, Francisco Inácio Pinkusfeld Monteiro | |
| Autor | Telles, Paulo R | |
| Autor | Castro Filho, Bernardo Galvão | |
| Autor | Diaz, Ricardo Sobhie | |
| Autor | Bongertz, Vera | |
| Autor | Morgado, Mariza Gonçalves | |
| Data de acesso | 2014-08-07T12:26:46Z | |
| Data de disponibilização | 2014-08-07T12:26:46Z | |
| Data do publicação | 2001 | |
| Citação | GUIMARÃES, M. L. et al. Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II. Journal of Clinical Virology, v. 21, n. 2, p. 143–151, 2001. | pt_BR |
| ISSN | 1386-6532 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8147 | |
| Idioma | eng | pt_BR |
| Editor | Elsevier | pt_BR |
| Direito Autoral | open access | pt_BR |
| Título | Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II. | pt_BR |
| Tipo do documento | Article | |
| Resumo em Inglês | BACKGROUND: Retrovirus infections among injecting drug users (IDUs), a core at-risk population for both HIV-1 and HTLV-I/II infections in Brazil, were assessed within an ongoing cooperative research. OBJECTIVE: The study assessed the seroprevalences of HIV-1 and HTLV-I/II infections, as well as the prevalence of HIV-1 subtypes in a sample of IDUs from Rio de Janeiro, Brazil. An attempt to evaluate HIV incidence was carried out using a dual 'sensitive/less sensitive' testing strategy. STUDY DESIGN: Cross-sectional evaluation of 175 IDUs. Serostatus for HIV-1 and HTLV-I/II were established by enzyme-linked immunosorbent assays, and confirmed by western blot. The dual testing strategy aimed to estimate HIV-1 incidence rates. Differentiation between HTLV-I and -II was performed by western blot. DNA samples were polymerase chain reaction amplified by a nested protocol, and HIV-1 subtyping was determined by heteroduplex mobility assay. RESULTS: Forty-six and 29 samples were found to be, respectively, positive for HIV-1 and HTLV-I/II, 15 of them co-infected by both viruses. Among HTLV-I/II-infected patients, 75.9% were infected by HTLV-I. Thirty-one HIV samples were identified as B subtype, with seven of them showing the typical "Brazilian B" pattern in the gp120 V3 loop, and ten were identified as F subtype. The use of less sensitive assays for HIV infection wrongly identified a deeply immunocompromised patient as an incident case. CONCLUSION: Moderately high seroprevalences were found for both HIV-1 and HTLV-I/II infections, HIV-1/HTLV-I co-infections being of special concern. A non-statistically significant higher prevalence of F subtype was observed, when compared with the distribution of F/B subtypes among Brazilian patients from other exposure categories. No recent HIV-1 infections were detected, but a limitation of the "sensitive/less-sensitive" testing strategy was made evident. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. UNAIDS Collaborative Centre. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. UNAIDS Collaborative Centre. Center for Information on Science and Technology. Department of Health Information. Rio de Janeiro, RJ, Brasil | pt_BR |
| Afiliação | State Uni versity of Rio de Janeiro. Center for Drug Abuse Treatment and Research. NEPAD. Rio de Janeiro, RJ, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. UNAIDS Collaborative Centre. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Afiliação | Federal Uni ersity of São Paulo. Laboratory of Retro virology. São Paulo. SP, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. UNAIDS Collaborative Centre. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. UNAIDS Collaborative Centre. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil | pt_BR |
| Palavras-chave em inglês | Injecting drug users | pt_BR |
| Palavras-chave em inglês | HIV | pt_BR |
| Palavras-chave em inglês | HTLV | pt_BR |
| Palavras-chave em inglês | HIV/HTLV co-infection | pt_BR |
| Palavras-chave em inglês | Sensitive/less sensitive dual testing strategy for HIV infection | pt_BR |
| DeCS | Infecções por HIV/epidemiologia | pt_BR |
| DeCS | HIV-1/classificação | pt_BR |
| DeCS | Infecções por HTLV-I/epidemiologia | pt_BR |
| DeCS | Abuso de Substâncias por Via Intravenosa/complicações | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Brasil/epidemiologia | pt_BR |
| DeCS | Estudos Transversais | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Infecções por HIV/complicações | pt_BR |
| DeCS | Soroprevalência de HIV | pt_BR |
| DeCS | Infecções por HTLV-I/complicações | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Incidência | pt_BR |
