| Author | Bongertz, Vera | |
| Author | Costa, Catia Ines | |
| Author | Guimarães, Monick Lindenmeyer | |
| Author | Grinsztejn, Beatriz | |
| Author | João Filho, Esaú Custódio | |
| Author | Castro Filho, Bernardo Galvão | |
| Author | Morgado, Mariza Gonçalves | |
| Access date | 2014-08-12T13:58:33Z | |
| Available date | 2014-08-12T13:58:33Z | |
| Document date | 1998 | |
| Citation | BONGERTZ, V. et al. Neutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group. Scandinavian Journal of Immunology, v. 47, n. 6, p. 603-608, 1998. | pt_BR |
| ISSN | 0300-9475 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8189 | |
| Description | The HEC/FIOCRUZ Aids Clinical Research Groupp: V. G. V. SANTOS, V. C. Rolla, S. Cavalcante, M. C. G. Galhardo and M. R. C. Guimarães. | |
| Language | eng | pt_BR |
| Publisher | Blackwell Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Antígenos HIV | |
| Subject in Portuguese | HIV-1 | |
| Subject in Portuguese | Variação Antigênica | |
| Subject in Portuguese | Anticorpos Anti-HIV | |
| Subject in Portuguese | Isolamento | |
| Title | Neutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group | pt_BR |
| Type | Article | |
| DOI | 10.1046/j.1365-3083.1998.00345.x | |
| Abstract | Susceptibility to autologous and heterologous neutralization of primary human immunodeficiency virus (HIV)-1 isolates belonging to subtype B, to the B"-variant of subtype B or to subtype F from infected individuals residing in Rio de Janeiro was assayed. A lower infectivity of the B"- and F isolates when compared to the classical B-subtype HIV-1 isolates was observed. Comparisons of neutralization susceptibilities were carried out for 19 B-subtype, 11 B"-variant and two F-subtype HIV-1 isolates with plasma from autologous and heterologous samples. Frequency of autologous neutralization was slightly lower for B-subtype isolates in comparison to B"-variant isolates. Heterologous intra-subtype neutralization was significantly lower for B-subtype than for the B"-variant or the F-subtype isolates. While B-subtype isolates were neutralized by most anti-F-subtype plasma, F-subtype isolates, although most susceptible to F-subtype antibodies, were highly susceptible to neutralization by anti-B-subtype antibodies. Cross-neutralization for B"-variant and B-subtype isolates was not as extensive as observed for B- and F-subtype isolates. However, the results presented indicate a quite extensive cross-neutralization between Brazilian HIV-1 isolates. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Servidores do Estado Hospital Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| DeCS | Antígenos HIV | pt_BR |
| DeCS | HIV-1 | pt_BR |
| DeCS | Variação Antigênica | pt_BR |
| DeCS | Anticorpos Anti-HIV | pt_BR |
| DeCS | Isolamento & purificação | pt_BR |
| DeCS | Testes de Neutralização | pt_BR |
| DeCS | Humanos | pt_BR |
