Author | Weber, Jonathan | |
Author | Fenyo, Eva-Maria | |
Author | Beddows, Simon | |
Author | Kaleebu, Pontiano | |
Author | Bjorndal, Asa | |
Author | Who Network for Hiv Isolation and Caracterization. Castro Filho, Bernardo Galvão | |
Access date | 2014-08-20T13:12:06Z | |
Available date | 2014-08-20T13:12:06Z | |
Document date | 1996 | |
Citation | WEBER, J. et al. Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype. The WHO network for HIV isolation and characterization. Journal of Virology, v. 70, n. 11, p. 7827-7832, 1996. | pt_BR |
ISSN | 0022-538X | |
URI | https://www.arca.fiocruz.br/handle/icict/8211 | |
Language | eng | pt_BR |
Publisher | American Society for Microbiology | pt_BR |
Rights | open access | pt_BR |
Title | Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype. The WHO network for HIV isolation and characterization. | pt_BR |
Type | Article | pt_BR |
Abstract | Human immunodeficiency virus type 1 (HIV-1) primary isolates from four geographical locations in Thailand, Brazil, Rwanda, and Uganda, representing genetic subtypes A, B, C, D, and E, were examined for autologous and heterologous neutralization by panels of human HIV+ polyclonal plasma. In independent linked experiments in three laboratories using diverse methodologies and common reagents, no defined pattern of genetic subtype-specific neutralization was observed. Most plasma tested were broadly cross-neutralizing across two or more genetic subtypes, although the titer of neutralization varied across a wide range. We conclude that the genetic subtypes of HIV-1 are not classical neutralization serotypes. | pt_BR |
Affilliation | Imperial College School of Medicine at St. Mary’s. Department of Communicable Diseases. London, United Kingdom | pt_BR |
Affilliation | Karolinska Institute. Microbiology and Tumour Biology Centre. Stockholm, Sweden | pt_BR |
Affilliation | Imperial College School of Medicine at St. Mary’s. Department of Communicable Diseases. London, United Kingdom | pt_BR |
Affilliation | Imperial College School of Medicine at St. Mary’s. Department of Communicable Diseases. London, United Kingdom | pt_BR |
Affilliation | Karolinska Institute. Microbiology and Tumour Biology Centre. Stockholm, Sweden | pt_BR |
Affilliation | World Health Organisation. Geneva, Switzerland / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
DeCS | Infecções por HIV/virologia | pt_BR |
DeCS | HIV-1/classificação | pt_BR |
DeCS | HIV-1/imunologia | pt_BR |
DeCS | Infecções por HIV/sangue | pt_BR |
DeCS | Infecções por HIV/imunologia | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Testes de Neutralização | pt_BR |
DeCS | Sorotipagem | pt_BR |