Author | Nomizo, Auro | |
Author | Cardillo, Fabíola | |
Author | Postol, Edilberto | |
Author | Pontes-de-Carvalho, Lain Carlos | |
Author | Mengele Junior, José Orivaldo | |
Access date | 2014-09-04T16:51:59Z | |
Available date | 2014-09-04T16:51:59Z | |
Document date | 2006 | |
Citation | NOMIZO, A. et al. Vg1 gd T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice. Microbes and Infection, v. 8, n. 3, p. 880-888, 2006. | pt_BR |
ISSN | 1286-4579 | |
URI | https://www.arca.fiocruz.br/handle/icict/8304 | |
Language | eng | pt_BR |
Publisher | Elsevier SAS | pt_BR |
Rights | open access | pt_BR |
Title | Vg1 gd T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.micinf.2005.10.012 | |
Abstract | Many different cell populations or lineages participate in the resistance to Trypanosoma cruzi infection. gammadelta T cells may also take part in a network of interactions that lead to control of T. cruzi infection with minimal tissue damage by controlling alphabeta T cell activation, as was previously suggested. However, the gammadelta T cell population is not homogeneous and its functions might vary, depending on T cell receptor usage or distinct stimulatory conditions. In this study, we show that the in vivo depletion of V gamma 1-bearing gammadelta T cells, prior to the infection of BALB/c mice with the Y strain of T. cruzi, induces an increased susceptibility to the infection with lower amounts of IFN-gamma being produced by conventional CD4+ or CD8+ T cells. In addition, the production of IL-4 by spleen T cells in V gamma 1-depleted mice was increased and the production of IL-10 remained unchanged. Since V gamma 1(+) gammadelta T cell depletion diminished the conversion of naive to memory/activated CD4 T cells and the production of IFN-gamma during the acute infection, these cells appear to function as helper cells for conventional CD4+ Th1 cells. Depletion of V gamma 1(+) cells also reduced the infection-induced inflammatory infiltrate in the heart and skeletal muscle. More importantly, V gamma 1(+) cells were required for up-regulation of CD40L in CD4+ and CD8+ T cells during infection. These results show that a subset of gammadelta T cells (V gamma 1(+)), which is an important component of the innate immune response, up-regulates the type 1 arm of the adaptative immune response, during T. cruzi infection. | pt_BR |
Affilliation | University of São Paulo. Department of Clinical Analysis, Toxicology and Bromatology. FCFRP. Ribeirão Preto, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | University of São Paulo. Institute for Biomedical Sciences IV. Department of Immunology. São Paulo, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | Susceptibility | pt_BR |
Subject | CD40L | pt_BR |
Subject | IFN-g | pt_BR |
Subject | IL-4 | pt_BR |
Subject | Gd T cells | pt_BR |
DeCS | Doença de Chagas/imunologia | pt_BR |
DeCS | Cardiopatias/imunologia | pt_BR |
DeCS | Inflamação/imunologia | pt_BR |
DeCS | Receptores de Antígenos de Linfócitos T gama-delta/metabolismo | pt_BR |
DeCS | Subpopulações de Linfócitos T/imunologia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Anticorpos Monoclonais/farmacologia | pt_BR |
DeCS | Ligante de CD40/metabolismo | pt_BR |
DeCS | Interferon gama/metabolismo | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos BALB C | pt_BR |
DeCS | Camundongos Nus | pt_BR |
DeCS | Músculo Esquelético/metabolismo | pt_BR |
DeCS | Baço/citologia | pt_BR |
DeCS | Subpopulações de Linfócitos T/efeitos de drogas | pt_BR |
DeCS | Regulação para Cima | pt_BR |