| Author | Assis, Diana Cavalcante Miranda de | |
| Author | Lima, Êmyle Martins | |
| Author | Goes, Bruno Teixeira | |
| Author | Cavalcanti, João Zugaib | |
| Author | Paixão, Alaí Barbosa | |
| Author | Santos, Marcos André Vannier dos | |
| Author | Martinez, Ana Maria Blanco | |
| Author | Baptista, Abrahão Fontes | |
| Access date | 2014-09-12T17:04:04Z | |
| Available date | 2014-09-12T17:04:04Z | |
| Document date | 2014 | |
| Citation | ASSIS, D. C. M. et al. The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice. Biomedical Research International, p. 572949, 2014. | pt_BR |
| ISSN | 2314-6141 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8367 | |
| Language | eng | pt_BR |
| Publisher | Hindawi Publishing Corporation | pt_BR |
| Rights | open access | pt_BR |
| Title | The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1155/2014/572949 | |
| Abstract | We investigated the effect of two frequencies of transcutaneous electrical nerve stimulation (TENS) applied immediately after lesion on peripheral nerve regeneration after a mouse sciatic crush injury. The animals were anesthetized and subjected to crushing of the right sciatic nerve and then separated into three groups: nontreated, Low-TENS (4 Hz), and High-TENS (100 Hz). The animals of Low- and High-TENS groups were stimulated for 2 h immediately after the surgical procedure, while the nontreated group was only positioned for the same period. After five weeks the animals were euthanized, and the nerves dissected bilaterally for histological and histomorphometric analysis. Histological assessment by light and electron microscopy showed that High-TENS and nontreated nerves had a similar profile, with extensive signs of degeneration. Conversely, Low-TENS led to increased regeneration, displaying histological aspects similar to control nerves. High-TENS also led to decreased density of fibers in the range of 6-12 µm diameter and decreased fiber diameter and myelin area in the range of 0-2 µm diameter. These findings suggest that High-TENS applied just after a peripheral nerve crush may be deleterious for regeneration, whereas Low-TENS may increase nerve regeneration capacity. | pt_BR |
| Affilliation | Federal University of Bahia. Faculty of Medicine. Salvador, BA, Brazil /
Federal University of Bahia. Functional Electrostimulation Laboratory. Department of Biomorphology. Salvador, BA, Brazil | |
| Affilliation | Federal University of Bahia. Faculty of Medicine. Salvador, BA, Brazil /
Federal University of Bahia. Functional Electrostimulation Laboratory. Department of Biomorphology. Salvador, BA, Brazil | |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Bahian School of Medicine and Human Health. Biotechnology and Bioprospection Nucleus. Salvador, BA, Brazil | |
| Affilliation | University of São Paulo. Faculty of Medicine of Ribeirão Preto. Physiology and Synaptic Plasticity Laboratory. Department of Physiology. São Paulo, SP, Brazil | |
| Affilliation | Federal University of Bahia. Functional Electrostimulation Laboratory. Department of Biomorphology. Salvador, BA, Brazil | |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Biofísica Carlos Chagas Filho. Cidade Universitária. Rio de Janeiro, RJ, Brasil | |
| Affilliation | Federal University of Rio de Janeiro. Neuroregeneration and Repair Laboratory. Cidade Universitária. Rio de Janeiro, RJ, Brazil | |
| DeCS | TENS | pt_BR |
| DeCS | Estimulação elétrica nervosa transcutânea | pt_BR |
| DeCS | Nervo ciático | pt_BR |
| DeCS | Microscopia eletrônica | pt_BR |
| DeCS | Doenças dos nervos periféricos | pt_BR |
| DeCS | Nervos periféricos | pt_BR |
| DeCS | Regeneração nervosa | pt_BR |
