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AutorSantana, Iuri Usêda
AutorGomes, Alline do Nascimento
AutorLyrio, Leomar D'Cirqueira
AutorGrassi, Maria Fernanda Rios
AutorSantiago, Mittermayer Barreto
Fecha de acceso2014-10-06T19:23:02Z
Fecha de disponibilización2014-10-06T19:23:02Z
Fecha de publicación2010
ReferenciaSANTANA, I. U. et al. Systemic lupus erythematosus, human papillomavirus infection, cervical pre-malignant and malignant lesions: a systematic review. Clinical Rheumatology, v. 30, n. 5, p. 665-672, 2011.pt_BR
ISSN1434-9949
URIhttps://www.arca.fiocruz.br/handle/icict/8519
Idiomaengpt_BR
EditorSpringerpt_BR
Derechos de autoropen accesspt_BR
TítuloSystemic lupus erythematosus, human papillomavirus infection, cervical pre-malignant and malignant lesions: a systematic review.pt_BR
Tipo del documentoArticlept_BR
DOI10.1007/s10067-010-1606-0
Resumen en InglésThe purpose of this study was to review and evaluate systematically the scientific evidence on the relationship between systemic lupus erythematosus (SLE), human papillomavirus (HPV) infection, pre-cancerous cervical abnormalities, and cervical cancer. Establishing strict inclusion and exclusion criteria, we performed an extensive search for studies in MEDLINE and BIREME databases to assess the studies that evaluated the frequency of HPV infection, pre-cancerous cervical abnormalities, and cervical cancer in women with SLE. Secondary references were additionally obtained from the included articles. Thirty-three articles met the criteria previously established. Fifteen out of 18 studies that performed cytological analysis showed a higher frequency of squamous intraepithelial lesions in SLE patients compared with normal women. Moreover, three studies found a higher frequency of high-grade squamous intraepithelial lesions. Additionally, it was observed that women with SLE had a higher frequency of HPV infection, confirmed by molecular biology techniques. Curiously, despite the above findings, no increased frequency of cervical cancer was observed in the majority of the studies which addressed this issue. Five studies observed a relationship between cervical abnormalities and previous use of immunosuppressive drugs. This review suggests that SLE patients seem not to be at increased risk for developing cervical cancer; however, they should be considered at higher risk for HPV infection and cervical dysplasia than the general population. Thus, gynecological visits at shorter intervals seem to be a reasonable approach for those patients.pt_BR
AfiliaciónEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasilpt_BR
AfiliaciónEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasilpt_BR
AfiliaciónEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasilpt_BR
AfiliaciónServiço de Reumatologia do Hospital do Santa Izabel. Salvador, BA, Brasilpt_BR
Palavras clave en InglêsCancerpt_BR
Palavras clave en InglêsCervical intraepithelial neoplasiapt_BR
Palavras clave en InglêsDysplasiapt_BR
Palavras clave en InglêsHuman papillomaviruspt_BR
Palavras clave en InglêsSquamous intraepithelial lesionpt_BR
Palavras clave en InglêsSystemic lupus erythematosuspt_BR
DeCSNeoplasia Intraepitelial Cervical/epidemiologiapt_BR
DeCSLúpus Eritematoso Sistêmico/epidemiologiapt_BR
DeCSInfecções por Papillomavirus/epidemiologiapt_BR
DeCSNeoplasias do Colo do Útero/epidemiologiapt_BR
DeCSEstudos de Casos e Controlespt_BR
DeCSNeoplasia Intraepitelial Cervical/terapiapt_BR
DeCSEstudos Transversaispt_BR
DeCSFemininopt_BR
DeCSHumanospt_BR
DeCSImunossupressores/farmacologiapt_BR
DeCSLúpus Eritematoso Sistêmico/terapiapt_BR
DeCSPapillomaviridae/genéticapt_BR
DeCSInfecções por Papillomavirus/terapiapt_BR
DeCSProjetos de Pesquisapt_BR
DeCSEstudos Retrospectivospt_BR
DeCSRiscospt_BR
DeCSResultado do Tratamentopt_BR
DeCSNeoplasias do Colo do Útero/prevenção & controlept_BR


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