| Author | Dantas, Eduardo Miranda | pt_BR |
| Author | Pimentel, Enildo Broetto | pt_BR |
| Author | Andreão, Rodrigo Varejão | pt_BR |
| Author | Cichoni, Bruna Sgaria | pt_BR |
| Author | Gonçalves, Christine Pereira | pt_BR |
| Author | Zaniqueli, Divanei dos Anjos | pt_BR |
| Author | Baldo, Marcelo Perim | pt_BR |
| Author | Rodrigues, Sérgio Lamêgo | pt_BR |
| Author | Mill, José Geraldo | pt_BR |
| Access date | 2014-11-06T17:31:57Z | |
| Available date | 2014-11-06T17:31:57Z | |
| Document date | 2013 | |
| Citation | DANTAS, Eduardo Miranda. et al. Carvedilol recovers normal blood pressure variability in rats with myocardial infarction. Autonomic Neuroscience: Basic and Clinical, v. 117, p. 231-236, 2013. | pt_BR |
| ISSN | 1566-0702 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/8748 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Title | Carvedilol recovers normal blood pressure variability in rats with myocardial infarction | pt_BR |
| Type | Article | |
| Abstract | Background: The aim of this study was to investigate the effects of chronic treatment with carvedilol in blood
pressure (BPV) and heart rate (HRV) variability of rats with myocardial infarction (MI).
Methods: MI was produced in male rats by ligature of anterior interventricular branch of left coronary artery.
Control rats were submitted to a sham surgery (SO). MI and SO rats were randomized to receive for 30 days
placebo (Plac 0.5% metilcelulose) or carvedilol (Carv, 2 mg/Kg body weight/day, drinking water): SO-Plac
(N = 10), SO-Carv (N = 10), MI-Plac (N = 12), MI-Carv (N = 13). Blood pressure (BP) was directly
recorded in the awake animals and BPV was determined, in time (variance, mmhg2) and frequency domains
by the autoregressive method. Statistical significance was set in P b 0.05. Data are median and interquartile
range.
Results: No significant changes in HRV was observed in MI rats, while BPV showed significant decreasing of
blood pressure variance (SO-Plac = 42.08 (39.21) mmHg2 vs. MI-Plac = 21.67 (12.58) mmHg2, P b 0.05),
reversed by the Carv treatment (MI-Plac = 21.67 (12.58) vs. MI-Carv = 38.64 (29.25), P b 0.05). In the frequency
domain analyses, MI reduced absolute and normalized LF component (LF (mmHg2): SO-Plac = 8.98
(14.84) vs. MI-Plac = 2.08 (4.84), P b 0.05; LF(nu): SO-Plac = 79.48 (45.03) nu vs. MI-Plac = 24.25 (40.67)
nu, P b 0.05) and increased the normalized HF component of the BPV (SO-Plac = 20.51 (39.18) vs.
MI-Plac = 60.51 (39.73). Carv treatment significantly attenuated the LF component fall.
Conclusion: Chronic treatment with carvedilol restored the variance of BPV altered by the MI. | pt_BR |
| Affilliation | Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil. | pt_BR |
| Affilliation | Instituto Federal do Espírito Santo. Vitória, ES, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil. | pt_BR |
| Subject | Arterial Blood Pressure | pt_BR |
| Subject | Autonomic Nervous System | pt_BR |
| Subject | Power Spectral Analysis | pt_BR |
| Subject | Beta-Blocker Therapy | pt_BR |
| DeCS | Pressão Arterial | pt_BR |
| DeCS | Sistema Nervoso Autônomo | pt_BR |
| DeCS | Análise Espectral | pt_BR |
