| Author | Teixeira, Clarissa Romero | |
| Author | Gomes, Regis Bernardo Brandim | |
| Access date | 2014-11-11T16:46:19Z | |
| Available date | 2014-11-11T16:46:19Z | |
| Document date | 2013 | |
| Citation | TEIXEIRA, C. R.; GOMES, R. B. B. Experimental models in vaccine research: malaria and leishmaniasis. Brazilian Journal of Medical Biological Research, v. 46, n. 2, p. 109-116, 2013. | pt_BR |
| ISSN | 1414-431X | |
| URI | https://www.arca.fiocruz.br/handle/icict/8790 | |
| Language | eng | pt_BR |
| Publisher | Associação Brasileira de Divulgação Científica | pt_BR |
| Rights | open access | pt_BR |
| Title | Experimental models in vaccine research: malaria and leishmaniasis. | pt_BR |
| Type | Article | pt_BR |
| DOI | dx.doi.org/10.1590/1414-431X20122460 | |
| Abstract | Animal models have a long history of being useful tools, not only to test and select vaccines, but also to help understand the
elaborate details of the immune response that follows infection. Different models have been extensively used to investigate
putative immunological correlates of protection against parasitic diseases that are important to reach a successful vaccine. The
greatest challenge has been the improvement and adaptation of these models to reflect the reality of human disease and
the screening of vaccine candidates capable of overcoming the challenge of natural transmission. This review will discuss the
advantages and challenges of using experimental animal models for vaccine development and how the knowledge achieved
can be extrapolated to human disease by looking into two important parasitic diseases: malaria and leishmaniasis. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Subject | Human vaccines | pt_BR |
| Subject | Animal models | pt_BR |
| Subject | Malaria | pt_BR |
| Subject | Leishmaniasis | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
