Author | Luna, Karla Patrícia de Oliveira | |
Author | Melo, Cristiane ML | |
Author | Pascoal, Vanessa Peruhype Magalhães | |
Author | Martins Filho, Olindo Assis | |
Author | Pereira, Valéria Rêgo Alves | |
Access date | 2014-11-12T12:19:19Z | |
Available date | 2014-11-12T12:19:19Z | |
Document date | 2011 | |
Citation | LUNA, Karla Patrícia de Oliveira et al. Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes. International Journal of Interferon, cytokine and mediator research, volume 3 p. 9-18, 2011. | pt_BR |
ISSN | 1179-139X | |
URI | https://www.arca.fiocruz.br/handle/icict/8798 | |
Language | eng | pt_BR |
Publisher | Universidade de São Paulo | pt_BR |
Rights | open access | pt_BR |
Title | Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes | pt_BR |
Type | Article | pt_BR |
DOI | 10.2147/IJICMR.S14331 | |
Abstract | Snake venom is a complex biological mixture used for immobilization and killing of prey for alimentation. Many effects are inflicted by this venom, such as coagulation, necrosis, bleeding, inflammation, and shock. This study aimed to evaluate the inflammatory activity promoted by Bothrops erythromelas and Crotalus durissus cascavella snake venom. It was observed that both B. erythromelas and C. d. cascavella venom induced higher interferon-gamma and interleukin-6 production. Nitric oxide (NO) was significantly produced only by B.erythromelas venom, which also showed a higher rate of cell death induction when compared with C. d. cascavella. Results showed that B. erythromelas and C. d. cascavella venom induced distinct response in vitro through cytokines and NO production. However, B. erythromelasinduces a proinflammatory response and a higher rate of cell death in relation to C. d. cascavella venom. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães Departamento de Imunologia. Pernambuco, Brazil/Universidade Estadual da Paraíba. Campina Grande, Brazil; | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães Departamento de Imunologia. Pernambuco, Brazil; | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães Departamento de Imunologia. Pernambuco, Brazil; | pt_BR |
Subject | snake venom | pt_BR |
Subject | Bothrops | pt_BR |
Subject | nitric oxide | pt_BR |
Subject | necrosis | pt_BR |
Subject | Crotalus | pt_BR |