| Author | Rego, Filipe Ferreira de Almeida | |
| Author | Miranda, Aline Mota | |
| Author | Santos, Edson de Souza | |
| Author | Castro Filho, Bernardo Galvão | |
| Author | Alcantara, Luiz Carlos Júnior | |
| Access date | 2014-11-18T18:41:00Z | |
| Available date | 2014-11-18T18:41:00Z | |
| Document date | 2010 | |
| Citation | REGO, F. F. A. et al. Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil. AIDS Research and Human Retroviruses, v. 26, n. 12, p. 1333-1339, 2010. | pt_BR |
| ISSN | 1931-8405 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8906 | |
| Language | eng | pt_BR |
| Publisher | Mary Ann Liebert, Inc | pt_BR |
| Rights | open access | pt_BR |
| Title | Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1089/aid.2009.0298 | |
| Abstract | HTLV–1/HIV-1 co-infection is associated with severe clinical manifestations, marked immunodeficiency, and
opportunistic pathogenic infections, as well as risk behavior. Salvador, the capital of the State of Bahia, Brazil,
has the highest HTLV-1 prevalence (1.74%) found in Brazil. Few studies exist which describe this co-infection
found in Salvador and its surrounding areas, much less investigate how these viruses circulate or assess the
relationship between them. To describe the epidemiological and molecular features of HTLV in HIV coinfected
women. To investigate the prevalence of HTLV/HIV co-infection in surrounding areas, as well as the
molecular epidemiology of HTLV, a cross sectional study was carried out involving 107 women infected with
HIV-1 from the STD/HIV/AIDS Reference Center located in the neighboring City of Feira de Santana. Patient
samples were submitted to ELISA, and HTLV infection was confirmed using Western Blot and Polymerase
Chain Reaction (PCR). Phylogenetic analysis using Neighbor-Joining (NJ) and Maximum Likelihood (ML) was
performed on HTLV LTR sequences in order to gain further insights about molecular epidemiology and the
origins of this virus in Bahia. Four out of five reactive samples were confirmed to be infected with HTLV-1,
and one with HTLV-2. The seroprevalence of HTLV among HIV-1 co-infected women was 4.7%. Phylogenetic
analysis of the LTR region from four HTLV-1 sequences showed that all isolates were clustered into the main
Latin American group within the Transcontinental subgroup of the Cosmopolitan subtype. The HTLV-2
sequence was classified as the HTLV-2c subtype. It was also observed that four HTLV/HIV-1 co-infected
women exhibited risk behavior with two having parenteral exposure, while another two were sex workers.
This article describes the characteristics of co-infected patients. This co-infection is known to be severe and
further studies should be conducted to confirm the suggestion that HTLV-1 is spreading from Salvador to
surrounding areas | pt_BR |
| Affilliation | HTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil / HTLV Center/ Bahia School of Medicine and Public Health/Bahia Foundation for Science Development. Salvador, Bahia, Brasil | pt_BR |
| Affilliation | HTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil / HTLV Center/ Bahia School of Medicine and Public Health/Bahia Foundation for Science Development. Salvador, Bahia, Brasil | pt_BR |
| Affilliation | HTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil | pt_BR |
| Affilliation | HTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil / HTLV Center/ Bahia School of Medicine and Public Health/Bahia Foundation for Science Development. Salvador, Bahia, Brasil | pt_BR |
| Affilliation | HTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil / HTLV Center/ Bahia School of Medicine and Public Health/Bahia Foundation for Science Development. Salvador, Bahia, Brasil / National Cancer Institute. National Institutes of Health. Bethesda, Maryland | pt_BR |
| DeCS | Infecções por HIV/complicações | pt_BR |
| DeCS | Infecções por HTLV-I/epidemiologia | pt_BR |
| DeCS | Vírus 1 Linfotrópico T Humano/isolamento & purificação | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Brasil | pt_BR |
| DeCS | Análise por Conglomerados | pt_BR |
| DeCS | Estudos Transversais | pt_BR |
| DeCS | Ensaio de Imunoadsorção Enzimática | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Genótipo | pt_BR |
| DeCS | Infecções por HIV/virologia | pt_BR |
| DeCS | HIV-1/isolamento & purificação | pt_BR |
| DeCS | Vírus 1 Linfotrópico T Humano/genética | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Meia-Idade | pt_BR |
| DeCS | Epidemiologia Molecular | pt_BR |
| DeCS | Dados de Sequência Molecular | pt_BR |
| DeCS | Filogenia | pt_BR |
| DeCS | RNA Viral/genética | pt_BR |
| DeCS | Análise de Sequência de DNA | pt_BR |
