| Author | Pereira, Francisco de Assis Caldas | |
| Author | Gurgel, Clarissa Araújo Silva | |
| Author | Ramos, Eduardo Antônio Gonçalves | |
| Author | Vidal, Manuela Torres Andion | |
| Author | Pinheiro, Antonio Luiz Barbosa | |
| Author | Jurisic, Vladimir | |
| Author | Sales, Caroline Brandi Schlaepfer | |
| Author | Cury, Patrícia Ramos | |
| Author | Santos, Jean Nunes dos | |
| Access date | 2014-11-19T17:02:21Z | |
| Available date | 2014-11-19T17:02:21Z | |
| Document date | 2012 | |
| Citation | PEREIRA, F. A. C. et al. Distribution of mast cells in benign odontogenic tumors. Tumour Biology, v. 33, n. 2, p. 455-461, 2012. | pt_BR |
| ISSN | 1423-0380 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8917 | |
| Language | eng | pt_BR |
| Publisher | Springer | pt_BR |
| Rights | open access | pt_BR |
| Title | Distribution of mast cells in benign odontogenic tumors. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1007/s13277-011-0274-2 | |
| Abstract | The aim of this study was to investigate the presence of mast cells in a series of odontogenic tumors. Forty-five cases of odontogenic tumors were investigated using immunohistochemistry for mast cell triptase, and differences between groups were statistically evaluated. Mast cells were present in 96% of odontogenic tumors. Mast cells present in solid ameloblastoma were observed in the tumor stroma surrounding more solid and follicular epithelial islands, with or without squamous metaplasia. The odontogenic mixoma showed few mast cells. In odontogenic tumors with a cystic structure, the mast cells were distributed throughout all areas of the lesions, mainly in keratocystic odontogenic tumor. In addition, the total density of mast cells between all odontogenic tumors showed no significant difference (p > 0.05). A greater mast cells distribution was found in keratocystic odontogenic tumor in relation to adenomatoid odontogenic tumor (p < 0.01), and when the unicystic ameloblastoma and keratocistic odontogenic tumor were compared to the odontogenic myxoma (p < 0.05). Syndrome keratocystic odontogenic tumor showed a higher mean of mast cells when compared with the other tumors of the sample. Mast cells values presented by syndrome keratocystic odontogenic tumor were significantly greater than those of the sporadic keratocystic odontogenic tumor that were not associated with the syndrome (p = 0.03). Mast cells are probably one of the major components of the stromal scaffold in odontogenic tumors. We found significant differences of mast cells between syndrome nonsyndrome keratocystic odontogenic tumors, although their distribution did not seem to have any influence on the biologic behavior of benign odontogenic tumors. | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Center of Biophotonic. Salvador, BA, Brasil | pt_BR |
| Affilliation | University of Kragujevac. School of Medicine. Belgrade, Serbia | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Periodontics. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil | pt_BR |
| Subject | Mast cell | pt_BR |
| Subject | Immunohistochemistry | pt_BR |
| Subject | Odontogenic tumors | pt_BR |
| Subject | Ameloblastomas | pt_BR |
| DeCS | Ameloblastoma/patologia | pt_BR |
| DeCS | Neoplasias Maxilomandibulares/patologia | pt_BR |
| DeCS | Mastócitos/citologia | pt_BR |
| DeCS | Tumores Odontogênicos/patologia | pt_BR |
| DeCS | Linhagem Celular Tumoral | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Imuno-Histoquímica/métodos | pt_BR |
| DeCS | Inflamação | pt_BR |
