| Author | Ferro, Zaquer Suzana Munhoz Costa | |
| Author | Cunha, Fernanda de Borba | |
| Author | Souza, Bruno Solano de Freitas | |
| Author | Leal, Marcos Maurício Tosta | |
| Author | Silva, Adelson Alves da | |
| Author | Kühn, Telma Ingrid Borges de Bellis | |
| Author | Forte, Andresa | |
| Author | Sekiya, Eliseo Joji | |
| Author | Soares, Milena Botelho Pereira | |
| Author | Santos, Ricardo Ribeiro dos | |
| Access date | 2014-11-24T17:59:13Z | |
| Available date | 2014-11-24T17:59:13Z | |
| Document date | 2014 | |
| Citation | FERRO, Zaquer Suzana Munhoz Costa et al. Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model. Cytotechnology, v. 66, n. 2, p. 193-199, 2014. | pt_BR |
| ISSN | 0920-9069 | |
| ISSN | 10.1007/s10616-013-9557-3 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8952 | |
| Language | eng | pt_BR |
| Publisher | Springer Verlag | pt_BR |
| Rights | open access | pt_BR |
| Title | Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model | pt_BR |
| Type | Article | pt_BR |
| Abstract | Status epilepticus (SE) is a condition of persistent seizure that leads to brain damage and, frequently, to the establishment of chronic epilepsy. Cord blood is an important source of adult stem cells for the treatment of neurological disorders. The present study aimed to evaluate the effects of human umbilical cord blood mononuclear cells (HUCBC) transplanted into rats after induction of SE by the administration of lithium and pilocarpine chloride. Transplantation of HUCBC into epileptic rats protected against neuronal loss in the hippocampal subfields CA1, CA3 and in the hilus of the dentate gyrus, up to 300 days after SE induction. Moreover, transplanted rats had reduced frequency and duration of spontaneous recurrent seizures (SRS) 15, 120 and 300 days after the SE. Our study shows that HUCBC provide prominent antiepileptic and neuroprotective effects in the experimental model of epilepsy and reinforces that early interventions can protect the brain against the establishment of epilepsy. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hemocentro São Lucas. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | CordCell. Umbilical Cord Blood Stem Cell Center. São Paulo, SP, Brasil, | pt_BR |
| Affilliation | CordCell. Umbilical Cord Blood Stem Cell Center. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Hemocentro São Lucas. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil. | pt_BR |
| Subject | Epilepsy | pt_BR |
| Subject | Pilocarpine | pt_BR |
| Subject | Cord blood | pt_BR |
| Subject | Cell therapy | pt_BR |
| Subject | Neuroprotection | pt_BR |
| Subject | Seizure frequency | pt_BR |
| Subject | Neuronal loss | pt_BR |
