| Author | Adesse, Daniel Pedra | |
| Author | Goldenberg, Regina Coeli dos Santos | |
| Author | Fortes, Fabio da Silva de Azevedo | |
| Author | Jasmin | |
| Author | Iacobas, Dumitru Andrei | |
| Author | Iacobas, Sanda | |
| Author | Carvalho, Antonio Carlos Campos de | |
| Author | Meirelles, Maria de Nazareth Leal de | |
| Author | Huang, Huan | |
| Author | Soares, Milena Botelho Pereira | |
| Author | Tanowitz, Herbert Bernard | |
| Author | Garzoni, Luciana Ribeiro | |
| Author | Spray, David Conover | |
| Access date | 2014-11-27T18:39:27Z | |
| Available date | 2014-11-27T18:39:27Z | |
| Document date | 2011 | |
| Citation | ADESSE, D. P. et al. Gap junctions and chagas disease. Advances in Parasitology, v. 76, p. 63-81, 2011. | pt_BR |
| ISSN | 0065-308X | |
| URI | https://www.arca.fiocruz.br/handle/icict/8986 | |
| Language | spa | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Title | Gap junctions and chagas disease | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/B978-0-12-385895-5.00003-7. | |
| Abstract | Gap junction channels provide intercellular communication between cells. In the heart, these channels coordinate impulse propagation along the conduction system and through the contractile musculature, thereby providing synchronous and optimal cardiac output. As in other arrhythmogenic cardiac diseases, chagasic cardiomyopathy is associated with decreased expression of the gap junction protein connexin43 (Cx43) and its gene. Our studies of cardiac myocytes infected with Trypanosoma cruzi have revealed that synchronous contraction is greatly impaired and gap junction immunoreactivity is lost in infected cells. Such changes are not seen for molecules forming tight junctions, another component of the intercalated disc in cardiac myocytes. Transcriptomic studies of hearts from mouse models of Chagas disease and from acutely infected cardiac myocytes in vitro indicate profound remodelling of gene expression patterns involving heart rhythm determinant genes, suggesting underlying mechanisms of the functional pathology. One curious feature of the altered expression of Cx43 and its gene expression is that it is limited in both extent and location, suggesting that the more global deterioration in cardiac function may result in part from spread of damage signals from more seriously compromised cells to healthier ones. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Centro Universitario Stadual da Zona Oeste. Colegiado de Ciencias Biologicas e da Saude (CCBS). Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Albert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NEW York, USA | pt_BR |
| Affilliation | Albert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NEW York, USA | pt_BR |
| Affilliation | Albert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NEW York, USA | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Albert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NEW York, USA | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Albert Einstein College of Medicine. Department of Pathology. Bronx, New York, USA | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Albert Einstein College of Medicine. Department of Pathology. Bronx, New York, USA | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Albert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NEW York, USA | pt_BR |
| DeCS | Cardiomiopatia Chagásica/parasitologia | pt_BR |
| DeCS | Junções Gap/fisiologia | pt_BR |
| DeCS | Coração/fisiologia | pt_BR |
| DeCS | Coração/parasitologia | pt_BR |
| DeCS | Trypanosoma cruzi/patogenicidade | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Células Cultivadas | pt_BR |
| DeCS | Perfilação da Expressão Gênica | pt_BR |
| DeCS | Interações Hospedeiro-Patógeno | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Camundongos | pt_BR |
| DeCS | Células Musculares/parasitologia | pt_BR |
| DeCS | Células Musculares/fisiologia | pt_BR |
