Author | Azevedo Junior, Walter Filgueira de | |
Author | Soares, Milena Botelho Pereira | |
Access date | 2014-11-28T17:31:45Z | |
Available date | 2014-11-28T17:31:45Z | |
Document date | 2009 | |
Citation | AZEVEDO JUNIOR, W. F.; SOARES, M. B. P. Selection of targets for drug development against protozoan parasites. Current Drug Targets, v. 10, n. 3, p. 193-201, 2009. | pt_BR |
ISSN | 1873-5592 | |
URI | https://www.arca.fiocruz.br/handle/icict/9008 | |
Language | eng | pt_BR |
Publisher | Bentham Science Publishers Ltd | pt_BR |
Rights | open access | pt_BR |
Title | Selection of targets for drug development against protozoan parasites | pt_BR |
Type | Article | pt_BR |
Abstract | Sequencing of parasite genomes opened the possibity to identify potential protein targets for drug development.
Several protein targets have been found in the genome of Plasmodium falciparum, Trypanosoma cruzi, Trypanosoma
brucei and Leishmania major. Bioinformatics analysis is an important tool for the identification of protein targets for drug
development against parasitic diseases. In this review we comment about three protein targets, identified in parasite genomes,
and discuss the main features that may guide future efforts for virtual screening initiatives. | pt_BR |
Affilliation | Pontifícia Universidade Católica do Rio Grande do Sul. Faculdade de Biociências. Laboratório de Bioquímica Estrutural. Porto Alegre, RS, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Av. São Rafael. Salvador, BA, Brasil | pt_BR |
Subject | Virtual screening | pt_BR |
Subject | Parasites | pt_BR |
Subject | Molecular targets | pt_BR |
Subject | Drug design | pt_BR |
DeCS | Antiprotozoários/farmacologia | pt_BR |
DeCS | Sistemas de Liberação de Medicamentos | pt_BR |
DeCS | Infecções por Protozoários/quimioterapia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Desenho de Drogas | pt_BR |
DeCS | Genoma de Protozoário | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Dados de Sequência Molecular | pt_BR |
DeCS | Dados de Sequência Molecular | pt_BR |
DeCS | Proteínas Quinases/metabolismo | pt_BR |
DeCS | Infecções por Protozoários/parasitologia | pt_BR |
DeCS | Purina-Núcleosídeo Fosforilase/efeitos de drogas | pt_BR |
DeCS | Ácido Chiquímico/metabolismo | pt_BR |