| Author | Silva, Fabrício S | |
| Author | Sá, Matheus Santos de | |
| Author | Costa, José Fernando Oliveira | |
| Author | Pinto, Fernanda P | |
| Author | Lima, Milena da Silva | |
| Author | Lucchese, Angélica Maria | |
| Author | Góes Neto, Aristóteles | |
| Author | Zalis, Mariano Gustavo | |
| Author | Santos, Ricardo Ribeiro dos | |
| Author | Soares, Milena Botelho Pereira | |
| Access date | 2014-11-28T18:56:28Z | |
| Available date | 2014-11-28T18:56:28Z | |
| Document date | 2009 | |
| Citation | SILVA, F. S. et al. In vitro pharmacological screening of macrofungi extracts from the Brazilian northeastern region. Pharmaceutical Biology, v. 47, n. 5, p. 384–389, 2009. | pt_BR |
| ISSN | 1873-5592 | |
| URI | https://www.arca.fiocruz.br/handle/icict/9011 | |
| Language | eng | pt_BR |
| Publisher | Bentham Science Publishers Ltd | pt_BR |
| Rights | open access | pt_BR |
| Title | In vitro pharmacological screening of macrofungi extracts from the Brazilian northeastern region | pt_BR |
| Type | Article | pt_BR |
| Abstract | Although the use of macrofungi in popular medicine is very common, especially in East Asia, the knowledge
about their pharmacological properties is poorly investigated. The aim of this work was to evaluate
the pharmacological potential of six species of macroscopic fungi: Phellinus rimosus (Berk.) Pilát
(Hymenochaetaceae), Pycnoporus sanguineus (L.) Murrill (Poyporaceae), Hymenochaete rheicolor (Mont.)
Lév. (Hymenochaetaceae), Hexagonia papyracea Berk. (Polyporaceae), Datronia caperata (Berk.) Ryvarden
(Polyporaceae), and Lepiota sp. (Agaricaceae), collected in the state of Bahia, in north-eastern Brazil. Extracts
of these species were obtained and tested to determine their cytotoxicity in normal mouse spleen cells.
Immunomodulatory, antineoplasic and antiparasitic activities were investigated. Four macrofungi extracts
(Phellinus rimosus, Hymenochaete rheicolor, Lepiota sp., and Datronia caperata) inhibited the lymphoproliferative
response stimulated by concanavalin A in 65–96% of inhibition in mitogen-induced lymphoproliferation
assay, three (Hymenochaete rheicolor, Pycnoporus sanguineus, and Lepiota sp.) inhibited 60–70% of
production of nitric oxide by J774 activated by IFN-γ and LPS, and two (Phellinus rimosus and Pycnoporus
sanguineus) had antimalarial activity against chloroquine-resistant Plasmodium falciparum (over 60%). We
did not find inhibition greater than 60% to the growth of both Leishmania amazonensis and Trypanosoma
cruzi. To our knowledge, this is the first description of immunomodulatory activity of Hymenochaete rheicolor
(HR), Datronia caperata (DC) and Pycnoporus sanguineus (PS). These results indicate that macrofungi
species from the Brazilian north-east have pharmacological activity and are thus a potential source of natural
products with medicinal interest. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Estadual de Feira de Santana. Laboratório de Química de Produtos Naturais e Bioativos. Feira de Santana, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Estadual de Feira de Santana. Laboratório de Química de Produtos Naturais e Bioativos. Feira de Santana, BA, Brasil | pt_BR |
| Affilliation | Universidade Estadual de Feira de Santana. Laboratório de Pesquisa em Microbiologia. Feira de Santana, BA, Brasi | pt_BR |
| Affilliation | Hospital Universitário Clementino Fraga Filho. Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil | pt_BR |
| Subject | Basidiomycota | pt_BR |
| Subject | Antiparasitic activity | pt_BR |
| Subject | Immunomodulation | pt_BR |
| Subject | Pharmacological screening | pt_BR |
