| Author | Ricci, Natasha Delaqua | |
| Author | Fiuza, Jacqueline Araujo | |
| Author | Bueno, Lilian Lacerda | |
| Author | Cançado, Guilherme Grossi Lopes | |
| Author | Guimaraes, Pedro Henrique Gazzinelli | |
| Author | Martins, Virgillio Gandra | |
| Author | Matoso, Leonardo Ferreira | |
| Author | Miranda, Rodrigo Rodrigues Cambraia de | |
| Author | Geiger, Stefan Michael | |
| Author | Oliveira, Rodrigo Corrêa | |
| Author | Gazzinelli, Andréa Pereira | |
| Author | Fujiwara, Ricardo Toshio | |
| Author | Bartholomeu, Daniella Castanheira | |
| Access date | 2014-12-02T13:07:36Z | |
| Available date | 2014-12-02T13:07:36Z | |
| Document date | 2011 | |
| Citation | RICCI, Natasha Delaqua et al. Induction of CD4+CD25+FOXP3+ Regulatory T Cells during Human Hookworm Infection Modulates Antigen-Mediated Lymphocyte Proliferation. PLOS NEGLECT TROP D, v. 5, n. 11, p. e1383, 2011. | pt_BR |
| ISSN | 1935-2735 | |
| URI | https://www.arca.fiocruz.br/handle/icict/9027 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Title | Induction of CD4+CD25+FOXP3+ Regulatory T Cells during Human Hookworm Infection Modulates Antigen-Mediated Lymphocyte Proliferation. | pt_BR |
| Type | Article | pt_BR |
| Abstract | Hookworm infection is considered one of the most important poverty-promoting neglected tropical diseases, infecting 576 to 740 million people worldwide, especially in the tropics and subtropics. These blood-feeding nematodes have a remarkable ability to downmodulate the host immune response, protecting themselves from elimination and minimizing severe host pathology. While several mechanisms may be involved in the immunomodulation by parasitic infection, experimental evidences have pointed toward the possible involvement of regulatory T cells (Tregs) in downregulating effector T-cell responses upon chronic infection. However, the role of Tregs cells in human hookworm infection is still poorly understood and has not been addressed yet. In the current study we observed an augmentation of circulating CD4+ CD25+ FOXP3+ regulatory T cells in hookworm-infected individuals compared with healthy non-infected donors. We have also demonstrated that infected individuals present higher levels of circulating Treg cells expressing CTLA-4, GITR, IL-10, TGF-b and IL-17. Moreover, we showed that hookworm crude antigen stimulation reduces the number of CD4+ CD25+ FOXP3+ T regulatory cells co-expressing IL-17 in infected individuals. Finally, PBMCs from infected individuals pulsed with excreted/secreted products or hookworm crude antigens presented an impaired cellular proliferation, which was partially augmented by the depletion of Treg cells. Our results suggest that Treg cells may play an important role in hookworm-induced immunosuppression, contributing to the longevity of hookworm survival in infected people. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil/ Instituto Nacional de Ciencia e Tecnologia em Doenças Tropicais. Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil/ Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil/ Instituto Nacional de Ciencia e Tecnologia em Doenças Tropicais. Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil/ Instituto Nacional de Ciencia e Tecnologia em Doenças Tropicais. Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Instituto Nacional de Ciencia e Tecnologia em Doenças Tropicais. Brazil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Instituto Nacional de Ciencia e Tecnologia em Doenças Tropicais. Brazil/Universidade Federal de Minas Gerais. Escola de Enfermagem. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciencia e Tecnologia em Doenças Tropicais. Brazil/ Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Human hookworm | pt_BR |
| Subject | Ancylostoma duodenale | pt_BR |
| Subject | Necator americanus | pt_BR |
| Subject | Hookworm antigen | pt_BR |
