Author | Machado Junior, Almério | |
Author | Emodi, Krisztina | |
Author | Takenami, Iukary Oliveira | |
Author | Finkmoore, Brook C. | |
Author | Bessa, Theolis Costa Barbosa | |
Author | Carvalho, J. | |
Author | Cavalcanti, Lara Almeida | |
Author | Santos, G. | |
Author | Tavares, M. | |
Author | Mota, M. | |
Author | Barreto, F. | |
Author | Reis, Mitermayer Galvão dos | |
Author | Arruda, Sérgio Marcos | |
Author | Riley, Lee Woodland | |
Access date | 2014-12-03T18:11:06Z | |
Available date | 2014-12-03T18:11:06Z | |
Document date | 2009 | |
Citation | MACHADO JUNIOR, Almério. Analysis of discordance between the tuberculin skin test and the interferon-gamma release assay. Int. J. Tuberc. Lung. Dis., v. 13, n. 4, p. 446-453, Apr. 2009. | pt_BR |
ISSN | 1027-3719 | |
URI | https://www.arca.fiocruz.br/handle/icict/9036 | |
Language | eng | pt_BR |
Publisher | The Union | pt_BR |
Rights | open access | pt_BR |
Title | Analysis of discordance between the tuberculin skin test and the interferon-gamma release assay | pt_BR |
Type | Article | pt_BR |
Abstract | To analyze factors associated with discordance between tuberculin skin test (TST) and interferon-gamma release assay (IGRA) results among household contacts of pulmonary tuberculosis (PTB) patients. DESIGN: TST (purified protein derivative) and IGRA (QuantiFERON-TB Gold) were performed on household contacts of PTB patients diagnosed between 2006 and 2007 in Salvador, Brazil. Discordant test groups were compared with the TST-/IGRA- group. RESULTS: Of 261 household contacts satisfactorily tested by TST, 145 (55.6%) had positive TST results; of 298 satisfactorily tested by IGRA, 127 (43.1%) had positive results. The test agreement was 0.76 (kappa = 0.53, 95%CI 0.43-0.63). Sixty-one (24%) were discordant: 44 (72%) with TST+/IGRA- and 17 (28%) with TST-/IGRA+ results. Compared to the TST-/IGRA- group, the TST+/IGRA- and TST+/IGRA+ groups were significantly more likely to have a chest X-ray showing old lung scars (OR = 6.8, 95%CI 1.3-35.0; OR = 7.4, 95%CI 2.2-24.4, respectively). The TST-/IGRA+ group was exposed to their index cases for significantly longer than the TST-/IGRA- group (OR = 7.2, 95%CI 1.7-29.3). CONCLUSION: The TST+/IGRA- and TST+/IGRA+ groups shared more similar characteristics with each other than with the TST-/IGRA- group. In a setting endemic for TB, TST results appear to be more suitable in the decision to treat latent TB infection. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Salvador, BA, Brasil. | pt_BR |
Affilliation | School of Public Health, University of California, Berkeley. California, USA. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Affilliation | School of Public Health, University of California, Berkeley. California, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Subject | Latent tuberculosis infection | pt_BR |
Subject | Interferongamma release assay | pt_BR |
Subject | Tuberculin skin test | pt_BR |
Subject | Household contacts | pt_BR |
DeCS | Interferon gama/sangue | pt_BR |
DeCS | Teste Tuberculínico | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Pré-Escolar | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Lactente | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Tuberculose Pulmonar/diagnóstico | pt_BR |