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AutorZanette, Angela Maria Dias
AutorGonçalves, Marilda de Souza
AutorSchettini, Laíse Vilasboas
AutorAguiar, Lais Magalhães
AutorBahia, Regina Célia Santos
AutorNogueira, Luciana Araujo Vasconcelos
AutorBrandão, Cláudio José de Freitas
AutorAzevedo, Ana Claudia Neves de
AutorAragao, Luciana Ramos de
AutorArruda, Sérgio Marcos
Fecha de acceso2014-12-04T14:30:30Z
Fecha de disponibilización2014-12-04T14:30:30Z
Fecha de publicación2010
ReferenciaZANETTE, A. M. D. et al. Alloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil. Ethnicity & Disease, v. 20, n. 2, p. 136-141, 2010.pt_BR
ISSN1049-510X
URIhttps://www.arca.fiocruz.br/handle/icict/9043
Idiomaengpt_BR
EditorInternational Society on Hypertension in Blackspt_BR
Derechos de autoropen accesspt_BR
TítuloAlloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil.pt_BR
Tipo del documentoArticlept_BR
Resumen en InglésSickle cell disease (SCD) is an important public health issue in Bahia, Brazil. Erythrocyte transfusions may reduce morbidity of SCD, however, they are associated with numerous risks. Among other risk categories, alloimmunization to red cell antigens may result from transfusions. The aim of this study was to compare the clinical profile of transfused adult SCD patients with and without alloantibodies. The study included 108 patients (105 homozygous SS and three with hemoglobinopathy SC), followed in the Outpatient Unit of the Hematology and Hemotherapy Center of Bahia. A retrospective review of clinical records of adult SCD patients who received at least three red blood cell transfusions from 2004 to 2007 was performed. Transfusion units were phenotypically matched for ABH-D and C,c,E,e, and K antigens. Alloimmunization developed in 56 patients (53 SS and three SC). The most prevalent alloantibodies were anti-E, anti-K, and anti-C (39.3%, 21.4%, and 16.1%, respectively). Age, sex and positive antiglobulin test displayed statistically significant differences. Prevalence of clinical complications such as leg ulcers, stroke, and others did not show differences between groups. In conclusion, alloimmunization did not significantly modify the clinical outcomes of SCD patients from Bahia, Brazil.pt_BR
AfiliaciónHematology and Hemotherapy Center of Bahia. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasilpt_BR
AfiliaciónMedicine School. Bahia Foundation for Science Development. Salvador, BA, Brasilpt_BR
AfiliaciónMedicine School. Bahia Foundation for Science Development. Salvador, BA, Brasilpt_BR
AfiliaciónHematology and Hemotherapy Center of Bahia. Salvador, BA, Brasilpt_BR
AfiliaciónHematology and Hemotherapy Center of Bahia. Salvador, BA, Brasilpt_BR
AfiliaciónHematology and Hemotherapy Center of Bahia. Salvador, BA, Brasilpt_BR
AfiliaciónHematology and Hemotherapy Center of Bahia. Salvador, BA, Brasilpt_BR
AfiliaciónHematology and Hemotherapy Center of Bahia. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasilpt_BR
Palavras clave en InglêsSickle Cell Diseasept_BR
Palavras clave en InglêsHemoglobinopathypt_BR
Palavras clave en InglêsAlloimmunizationpt_BR
Palavras clave en InglêsRed Cell Transfusionpt_BR
DeCSAnemia Falciforme/terapiapt_BR
DeCSTransfusão de Eritrócitos/efeitos adversospt_BR
DeCSIsoanticorpospt_BR
DeCSAdolescentept_BR
DeCSAdultopt_BR
DeCSAnemia Falciforme/complicaçõespt_BR
DeCSBrasil/epidemiologiapt_BR
DeCSTeste de Coombspt_BR
DeCSEstudos Transversaispt_BR
DeCSFemininopt_BR
DeCSHumanospt_BR
DeCSÚlcera da Perna/complicaçõespt_BR
DeCSMasculinopt_BR
DeCSMeia-Idadept_BR
DeCSAmbulatório Hospitalar/estatística & dados numéricospt_BR
DeCSPrevalênciapt_BR
DeCSEstudos Retrospectivospt_BR
DeCSAcidente Vascular Cerebral/complicaçõespt_BR
DeCSAdulto Jovempt_BR


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