| Author | Carvalho, Manoel de | |
| Author | Mochdece, Christieny Chaipp | |
| Author | Sá, Cynthia Amaral Moura | |
| Author | Moreira, Maria Elisabeth Lopes | |
| Access date | 2014-12-19T13:12:26Z | |
| Available date | 2014-12-19T13:12:26Z | |
| Document date | 2011 | |
| Citation | CARVALHO, Manoel de. et al. High-intensity phototherapy for the treatment of severe nonhaemolytic neonatal hyperbilirubinemia. High-intensity phototherapy for the treatment of severe nonhaemolytic neonatal hyperbilirubinemia. v. 100, p. 620–623, 2011. | pt_BR |
| ISSN | 10.1111/j.1651-2227.2011.02170.x | |
| URI | https://www.arca.fiocruz.br/handle/icict/9221 | |
| Language | eng | pt_BR |
| Publisher | John Wiley & Sons | |
| Rights | restricted access | pt_BR |
| Title | High-intensity phototherapy for the treatment of severe nonhaemolytic neonatal hyperbilirubinemia | pt_BR |
| Type | Article | pt_BR |
| Abstract | Aim: To describe the clinical approach to term and near-term newborn infants with
severe hyperbilirubinaemia and to analyse the effect of high-intensity phototherapy on total
serum bilirubin (TSB) levels.
Methods: We analysed a cohort of 116 newborn infants with severe nonhaemolytic
hyperbilirubinaemia (TSB‡20 mg⁄dL⁄342lmol⁄L). All patients were treated with high-intensity phototherapy. The main outcomes were reduction in TSB levels in the first 24 h of
phototherapy, incidence of exchange transfusion, pathological brainstem auditory evoked
responses and pathological findings on neurological examination at discharge.
Results: The mean birth weight and gestational age were 3161 ± 466 g and
37.8 ± 1.6 weeks. Mean initial TSB concentration was 22.4 ± 2.4 mg⁄dL. Per cent
decreases in TSB after 2, 4, 6, 12, 18 and 24 h of phototherapy were 9.4%, 16%, 23%,
40%, 44% and 50%, respectively. No infant was treated with exchange transfusion. Brain-stem evoked response audiometry (BAER) was performed in 100% of the patients, and in
three of them, this examination was altered. However, when repeated 3 months later,
these BAER examinations were normal. Neurological examination was normal in all
patients.
Conclusions: High-intensity phototherapy significantly reduces TSB in nonhaemolytic severe
hyperbilirubinaemia and decreases the need for exchange transfusion. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Department of Neonatology. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Department of Neonatology. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Department of Neonatology. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Department of Neonatology. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Brainstem Evoked Response Audiometry | pt_BR |
| Subject | Exchange Transfusion | pt_BR |
| Subject | Neonatal Hyperbilirubinaemia | pt_BR |
| Subject | Phototherapy | pt_BR |
| DeCS | Audiometria de Resposta Evocada | pt_BR |
| DeCS | Hiperbilirrubinemia | pt_BR |
| DeCS | Fototerapia | pt_BR |
