| Author | Carvalho, Cristiana Maria Costa Nascimento | |
| Author | Cardoso, Maria Regina Alves | |
| Author | Barral, Aldina Maria Prado | |
| Author | Araújo Neto, César Augusto de | |
| Author | Guerin, Sylvie | |
| Author | Saukkoriipi, Annika | |
| Author | Paldanius, Mika | |
| Author | Vainionpaa, Raija | |
| Author | Lebon, Pierre | |
| Author | Leinonen, Maija | |
| Author | Ruuskanen, Olli | |
| Author | Genfrel, Dominique | |
| Access date | 2014-12-22T18:47:43Z | |
| Available date | 2014-12-22T18:47:43Z | |
| Document date | 2010 | |
| Citation | NASCIMENTO-CARVALHO, C. M. et al. Procalcitonin is useful in identifying bacteraemia among children with pneumonia. Scandinavian Journal of Infectious Disease, v. 42, n. 9, p. 644-649, 2010. | pt_BR |
| ISSN | 1651-1980 | |
| URI | https://www.arca.fiocruz.br/handle/icict/9285 | |
| Language | eng | pt_BR |
| Publisher | Informa Healthcare | pt_BR |
| Rights | open access | pt_BR |
| Title | Procalcitonin is useful in identifying bacteraemia among children with pneumonia. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3109/00365541003796775 | |
| Abstract | Empirical antibiotic use is prescribed in managing children with pneumonia worldwide. We assessed the usefulness of
procalcitonin (PCT) and interferon-alpha (IFN- α ) in differentiating viral from bacterial pneumonia. Among 159 hospitalized
children, pneumonia was diagnosed based on clinical complaints plus pulmonary infi ltrate. Aetiology was investigated
for 9 viruses and 4 atypical and 3 typical bacteria. PCT and IFN- α were measured in the serum sample collected
on admission. Eight patients had bacteraemic infections, 38 had non-bacteraemic typical infections, and 19 patients had
atypical bacterial infections. Viral and unknown aetiology was established in 57 (36%) and 34 (21%) cases, respectively.
Three patients with bacterial infection without collected blood culture were excluded. IFN- α (IU/ml) was detectable in
20 (13%) cases. The difference among median PCT values of the bacteraemic (4.22; 1.56 – 7.56), non-bacteraemic
typical bacterial (1.47; 0.24 – 4.07), atypical bacterial (0.18; 0.06 – 1.03) and only viral (0.65; 0.11 – 2.22) subgroups was
signifi cant ( p 0.02). PCT was 2 ng/ml in 52 (33%) cases. The presence of IFN- α was associated with PCT 2 ng/ml
(90% vs. 64%, p 0.02). The negative predictive value (95% confi dence interval) of PCT 2 ng/ml was 95%
(89 – 100%), 89% (78 – 100%), 93% (85 – 100%) for differentiation of bacteraemic from viral, atypical bacterial and nonbacteraemic
typical bacterial infection, respectively, and 58% (49 – 68%) for differentiation between bacterial and viral
infection. PCT may be useful in identifying bacteraemia among children hospitalized with community-acquired pneumonia.
IFN- α was uncommonly detected. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Escola de Medicina Veterinária. Departamento de Pediatria. Salvador, BA, Brasil | pt_BR |
| Affilliation | São Paulo University. Faculty of Public Health. Epidemiology Department. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Escola de Medicina. Departamento de Diagnóstico de Patologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Escola de Medicina Veterinária. Departamento de Diagnóstico de Imagem. Salvador, BA, Brasil | pt_BR |
| Affilliation | Paris Descartes University. St Vincent-Cochin Hospital. Paris, France | pt_BR |
| Affilliation | National Institute for Health and Welfare. Oulu, Finland | pt_BR |
| Affilliation | National Institute for Health and Welfare. Oulu, Finland | pt_BR |
| Affilliation | University of Turku. Virology. Turku, Finland | pt_BR |
| Affilliation | Paris Descartes University. St Vincent-Cochin Hospital. Paris, France | pt_BR |
| Affilliation | National Institute for Health and Welfare. Oulu, Finland | pt_BR |
| Affilliation | University of Turku. Paediatrics Department. Turku, Finland | pt_BR |
| Affilliation | Paris Descartes University. St Vincent-Cochin Hospital. Paris, France | pt_BR |
| DeCS | Bacteriemia/diagnóstico | pt_BR |
| DeCS | Calcitonina/sangue | pt_BR |
| DeCS | Pneumonia Bacteriana/diagnóstico | pt_BR |
| DeCS | Pneumonia Viral/diagnóstico | pt_BR |
| DeCS | Precursores de Proteínas/sangue | pt_BR |
| DeCS | Bacteriemia/sangue | pt_BR |
| DeCS | Pré-Escolar | pt_BR |
| DeCS | Infecções Comunitárias Adquiridas/sangue | pt_BR |
| DeCS | Infecções Comunitárias Adquiridas/diagnóstico | pt_BR |
| DeCS | Diagnóstico Diferencial | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Lactente | pt_BR |
| DeCS | Recém-Nascido | pt_BR |
| DeCS | Interferon-alfa/sangue | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Pneumonia Bacteriana/sangue | pt_BR |
| DeCS | Pneumonia Bacteriana/microbiologia | pt_BR |
| DeCS | Valor Preditivo dos Testes | pt_BR |
| DeCS | Estudos Prospectivos | pt_BR |
| DeCS | Curva ROC | pt_BR |
| DeCS | Reprodutibilidade dos Testes | pt_BR |
| DeCS | Estatísticas não Paramétricas | pt_BR |
