Author | Vercruysse, Jozef | |
Author | Behnke, Jerzy M. | |
Author | Albonico, Marco | |
Author | Ame, Shaali Makame | |
Author | Angebault, Cécile | |
Author | Bethony, Jeffrey Michael | |
Author | Engels, Dirk | |
Author | Guillard, Bertrand | |
Author | Hoa, Nguyen Thi Viet | |
Author | Kang, Gagandeep | |
Author | Kattula, Deepthi | |
Author | Kotze, Andrew C. | |
Author | McCarthy, James S. | |
Author | Mekonnen, Zeleke | |
Author | Montresor, Antonio | |
Author | Periago, Maria Victoria | |
Author | Sumo, Laurentine | |
Author | Tchuenté, Louis-Albert Tchuem | |
Author | Thach, Dang Thi Cam | |
Author | Zeynudin, Ahmed | |
Author | levecke, Bruno | |
Access date | 2015-01-12T13:11:38Z | |
Available date | 2015-01-12T13:11:38Z | |
Document date | 2011 | |
Citation | VERCRUYSSE, Jozef F et al. Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic. PLOS NEGLECT TROP D 5(3): e948. | pt_BR |
ISSN | 1932-6203 | |
URI | https://www.arca.fiocruz.br/handle/icict/9370 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Title | Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pntd.0000948 | |
Abstract | Background: The three major soil-transmitted helminths (STH) Ascaris lumbricoides, Trichuris trichiura andNecator americanus/Ancylostoma duodenale are among the most widespread parasites worldwide. Despite the global expansion of preventive anthelmintic treatment, standard operating procedures to monitor anthelmintic drug efficacy are lacking. The objective of this study, therefore, was to define the efficacy of a single 400 milligram dose of albendazole (ALB) against these three STH using a standardized protocol.
Methodology/Principal Findings : Seven trials were undertaken among school children in Brazil, Cameroon, Cambodia, Ethiopia, India, Tanzania and Vietnam. Efficacy was assessed by the Cure Rate (CR) and the Fecal Egg Count Reduction (FECR) using the McMaster egg counting technique to determine fecal egg counts (FEC). Overall, the highest CRs were observed for A. lumbricoides (98.2%) followed by hookworms (87.8%) and T. trichiura (46.6%). There was considerable variation in the CR for the three parasites across trials (country), by age or the pre-intervention FEC (pre-treatment). The latter is probably the most important as it had a considerable effect on the CR of all three STH. Therapeutic efficacies, as reflected by the FECRs, were very high for A. lumbricoides (99.5%) and hookworms (94.8%) but significantly lower for T. trichiura (50.8%), and were affected to different extents among the 3 species by the pre-intervention FEC counts and trial (country), but not by sex or age.
Conclusions/Significance: Our findings suggest that a FECR (based on arithmetic means) of >95% for A. lumbricoidesand >90% for hookworms should be the expected minimum in all future surveys, and that therapeutic efficacy below this level following a single dose of ALB should be viewed with concern in light of potential drug resistance. A standard threshold for efficacy against T. trichiura has yet to be established, as a single-dose of ALB is unlikely to be satisfactory for this parasite. | pt_BR |
Affilliation | Ghent University. Faculty of Veterinary Medicine. Department of Virology, Parasitology and Immunology. Merelbeke, Belgium | pt_BR |
Affilliation | University of Nottingham. School of Biology. Nottingham, United Kingdom | pt_BR |
Affilliation | Ivo de Carneri. Public Health Laboratory. Pemba Island, Zanzibar, Tanzania | pt_BR |
Affilliation | Ivo de Carneri. Public Health Laboratory. Pemba Island, Zanzibar, Tanzania | pt_BR |
Affilliation | Institut Pasteur in Cambodia. Clinical Pathology Unit. Phnom Penh, Cambodia | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | World Health Organization. Department of Neglected Tropical Diseases. Geneva, Switzerland | pt_BR |
Affilliation | Institut Pasteur in Cambodia. Clinical Pathology Unit. Phnom Penh, Cambodia | pt_BR |
Affilliation | National Institute for Malariology, Parasitology and Entomology. Hanoi, Vietnam | pt_BR |
Affilliation | Christian Medical College. Department of Gastrointestinal Sciences. Vellore, India | pt_BR |
Affilliation | Christian Medical College. Department of Gastrointestinal Sciences. Vellore, India | pt_BR |
Affilliation | Commonwealth Scientific and Industrial Research Organisation. Division of Livestock Industries. Brisbane, Australia | pt_BR |
Affilliation | University of Queensland. Queensland Institute for Medical Research. Herston, Australia | pt_BR |
Affilliation | Jimma University. College of Public Health and Medical Sciences. Department of Medical Laboratory Sciences and Pathology. Jimma, Ethiopia | pt_BR |
Affilliation | World Health Organization. Department of Neglected Tropical Diseases. Geneva, Switzerland | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | University of Yaoundé I. Faculty of Sciences. Centre for Schistosomiasis and Parasitology. Cameroon | pt_BR |
Affilliation | University of Yaoundé I. Faculty of Sciences. Centre for Schistosomiasis and Parasitology. Cameroon | pt_BR |
Affilliation | National Institute for Malariology, Parasitology and Entomology. Hanoi, Vietnam | pt_BR |
Affilliation | Jimma University. College of Public Health and Medical Sciences. Department of Medical Laboratory Sciences and Pathology. Jimma, Ethiopia | pt_BR |
Affilliation | Ghent University. Faculty of Veterinary Medicine. Department of Virology, Parasitology and Immunology. Merelbeke, Belgium | pt_BR |
Subject | Ascaris lumbricoides | pt_BR |
Subject | Drug therapy | pt_BR |
Subject | Helminth infections | pt_BR |
Subject | Parasitic diseases | pt_BR |
Subject | Tanzania Trichuriasis | pt_BR |