| Author | Santos, Amélia Miyashiro Nunes dos | |
| Author | Guinsburg, Ruth | |
| Author | Almeida, Maria Fernanda Branco de | |
| Author | Procianoy, Renato S. | |
| Author | Leone, Cléa Rodrigues | |
| Author | Marba, Sérgio Tadeu Martins | |
| Author | Rugolo, Ligia Maria Suppo de Souza | |
| Author | Fiori, Humberto Holmer | |
| Author | Lopes, José Maria de Andrade | |
| Author | Martinez, Francisco Eulógio | |
| Access date | 2015-01-15T16:30:15Z | |
| Available date | 2015-01-15T16:30:15Z | |
| Document date | 2011 | |
| Citation | SANTOS, Amélia Miyashiro Nunes dos. et al. Red blood cell transfusions are independently associated with intra- hospital mortality in very low birth weight preterm infants. J. pediatr. (St. Louis)., St. Louis, v. 159, p. 371-376, 2011. | pt_BR |
| ISSN | 0022-3476 | |
| URI | https://www.arca.fiocruz.br/handle/icict/9392 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Title | Red blood cell transfusions are independently associated with intra- hospital mortality in very low birth weight preterm infants | pt_BR |
| Type | Article | |
| Abstract | Objective To test the hypothesis that red blood cell (RBC) transfusions in preterm infants are associated with increased
intra-hospital mortality.
Study design Variables associated with death were studied with Cox regression analysis in a prospective cohort
of preterminfants with birth weight <1500 g in the Brazilian Network on Neonatal Research. Intra-hospital death and
death after 28 days of life were analyzed as dependent variables. Independent variables were infant demographic
and clinical characteristics and RBC transfusions.
Results Of 1077 infants, 574 (53.3%) received at least one RBC transfusion during the hospital stay. The mean
number of transfusions per infant was 3.3 + 3.4, with 2.1 + 2.1 in the first 28 days of life. Intra-hospital death occurred
in 299 neonates (27.8%), and 60 infants (5.6%) died after 28 days of life. After adjusting for confounders,
the relative risk of death during hospital stay was 1.49 in infants who received at least one RBC transfusion in
the first 28 days of life, compared with infants who did not receive a transfusion. The risk of death after 28 days
of life was 1.89 times higher in infants who received more than two RBC transfusions during their hospital stay, compared
with infants who received one or two transfusions.
Conclusion Transfusion was associated with increased death, and transfusion guidelines should consider risks
and benefits of transfusion. | pt_BR |
| Affilliation | Universidade Federal de São Paulo. Departamento de Pediatria. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São Paulo. Departamento de Pediatria. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São Paulo. Departamento de Pediatria. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul. Departamento de Pediatria. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Departamento de Pediatria. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de Campinas. Departamento de Pediatria. Campinas, SP, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de São Paulo. Departamento de Pediatria. Botucatu, SP, Brasil. | pt_BR |
| Affilliation | Pontifícia Universidade Católica do Rio Grande do Sul. Departamento de Pediatria. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento Neonatal. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Departamento de Pediatria. Ribeirão Preto, SP, Brasil. | pt_BR |
| Subject | IVH | pt_BR |
| Subject | Intraventricular Hemorrhage | pt_BR |
| Subject | RBC | pt_BR |
| Subject | Red blood cell | pt_BR |
| Subject | SNAPPE II | pt_BR |
| Subject | Score for Neonatal Acute Physiology–Perinatal Extension | pt_BR |
| DeCS | Hemorragia | pt_BR |
| DeCS | Células | pt_BR |
