| Author | Figueiredo, Leandra Barcelos | |
| Author | Sakamoto, Tetsu | |
| Author | Coelho, Luiz Felipe Leomil | |
| Author | Rocha, Eliseu Soares de Oliveira | |
| Author | Cota, Marcela Menezes Gomes | |
| Author | Ferreira, Gustavo Portela | |
| Author | Oliveira, Jaquelline Germano de | |
| Author | Kroon, Erna Geessien | |
| Access date | 2015-02-13T12:51:43Z | |
| Available date | 2015-02-13T12:51:43Z | |
| Document date | 2014 | |
| Citation | FIGUEIREDO, Leandra Barcelos. Dengue Virus 2 American-Asian Genotype Identified during the 2006/2007 Outbreak in Piauı, Brazil Reveals a Caribbean Route of Introduction and Dissemination of Dengue Virus in Brazil. PLoS ONE, v. 9, n. 8, p. e104516. 2014 | pt_BR |
| ISSN | 1553-7366 | |
| URI | https://www.arca.fiocruz.br/handle/icict/9495 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Title | Dengue Virus 2 American-Asian Genotype Identified during the 2006/2007 Outbreak in Piauı´, Brazil Reveals a Caribbean Route of Introduction and Dissemination of Dengue Virus in Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pone.0104516 | |
| Abstract | Dengue virus (DENV) is the most widespread arthropod-borne virus, and the number and severity of outbreaks has increased worldwide in recent decades. Dengue is caused by DENV-1, DENV- 2, DENV-3 and DENV-4 which are genetically distant. The species has been subdivided into genotypes based on phylogenetic studies. DENV-2, which was isolated from dengue fever patients during an outbreak in Piaui, Brazil in 2006/2007 was analyzed by sequencing the envelope (E) gene. The results indicated a high similarity among the isolated viruses, as well as to other DENV-2 from Brazil, Central America and South America. A phylogenetic and phylogeographic analysis based on DENV-2E gene sequences revealed that these viruses are grouped together with viruses of the American-Asian genotype in two distinct lineages. Our results demonstrate the co-circulation of two American-Asian genotype lineages in northeast Brazil. Moreover, we reveal that DENV-2 lineage 2 was detected in Piauí before it disseminated to other Brazilian states and South American countries, indicating the existence of a new dissemination route that has not been previously described. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Laboratorio de Biodados. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Alfenas. Laboratorio de Vacinas. Alfenas, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Laboratorio de Vırus. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Laboratorio de Vırus. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal do Piauı. Laboratorio de Biotecnologia. Parnaıba, PI, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Laboratorio de Vırus. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Dengue vírus | pt_BR |
| Subject | Elisa PCR | pt_BR |
| Subject | LANL | pt_BR |
| Subject | Hemorrhagic Fever | pt_BR |
| Subject | Virus sequence database | pt_BR |
