| Author | Pimentel-Coelho, Pedro M. | |
| Author | Magalhães, Elizabeth S. | |
| Author | Lopes, Laudelino M. | |
| Author | Azevedo, Leonardo C. de | |
| Author | Santiago, Marcelo F. | |
| Author | Mendez-Otero, Rosalia | |
| Access date | 2015-02-25T13:30:58Z | |
| Available date | 2015-02-25T13:30:58Z | |
| Document date | 2010 | |
| Citation | PIMENTEL-COELHO, Pedro M. et al. Human cord blood transplantation in a neonatal rat model of hypoxic–ischemic brain damage: functional outcome related to neuroprotection in the striatum. Stem cells dev., Larchmont, v. 19, n. 3, 2010. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/9540 | |
| Language | eng | pt_BR |
| Publisher | Mary Ann Liebert | pt_BR |
| Rights | restricted access | |
| Title | Human cord blood transplantation in a neonatal rat model of hypoxic–ischemic brain damage: functional outcome related to neuroprotection in the striatum | pt_BR |
| Type | Article | |
| DOI | 10.1089/scd.2009.0049 | |
| Abstract | Human umbilical cord blood mononuclear cells (HUCB) have been shown to have a therapeutic role in different
models of central nervous system (CNS) damage, including stroke. We evaluated the possible therapeutic poten-tial of HUCB in P7 rats submitted to the Rice-Vannucci model of neonatal hypoxic–ischemic (HI) brain damage.
Our results demonstrated that intraperitoneal transplantation of HUCB, 3 h after the HI insult, resulted in better
performance in two developmental sensorimotor reflexes, in the first week after the injury. We also showed a
neuroprotective effect in the striatum, and a decrease in the number of activated microglial cells in the cerebral
cortex of treated animals. We suggest that HUCB transplantation might rescue striatal neurons from cell death
after a neonatal HI injury resulting in better functional recovery. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Instituto de Ciências Biomédicas. Programa de Terapia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Clínica Perinatal de Laranjeiras. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Programa de Terapia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Instituto de Ciências Biomédicas. Programa de Terapia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| DeCS | Transplante | pt_BR |
| DeCS | Cordão Umbilical | pt_BR |
| DeCS | Sistema Nervoso Central | pt_BR |
