Author | Oliveira, Graziela Teixeira de | |
Author | Ferreira, Jaqueline Maria Siqueira | |
Author | Rosa, Luiz Henrique | |
Author | Siqueira Filho, Ezequias Pessoa de | |
Author | Johann, Susana | |
Author | Lima, Luciana Alves Rodrigues dos Santos | |
Access date | 2015-02-25T18:37:02Z | |
Available date | 2015-02-25T18:37:02Z | |
Document date | 2014 | |
Citation | OLIVEIRA, Graziela Teixeira de. In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. Rev Soc Bras Med Trop. V. 47, n. 2, p. 247-250, 2014. | pt_BR |
ISSN | 0037-8682 | |
URI | https://www.arca.fiocruz.br/handle/icict/9543 | |
Language | eng | pt_BR |
Publisher | Sociedade Brasileira De Medicina Tropical | pt_BR |
Rights | open access | pt_BR |
Title | In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0037-8682-0008-2013 | |
Abstract | INTRODUCTION: There are few studies reporting the antifungal activities of Lippia alba extracts.
METHODS: A broth microdilution assay was used to evaluate the antifungal effects of Lippia alba extracts against seven yeast species of Candida and Cryptococcus. The butanol fraction was investigated by gas chromatography-mass spectrometry.
RESULTS: The butanol fraction showed the highest activity against Candida glabrata. The fraction also acted synergistically with itraconazole and fluconazole against C. glabrata. The dominant compounds in the butanol fraction were 2,2,5-trimethyl-3,4-hexanedione, 3,5-dimethyl-4-octanone and hexadecane.
CONCLUSIONS: The butanol fraction may be a good candidate in the search for new drugs from natural products with antifungal activity | pt_BR |
Affilliation | Universidade Federal de São João Del-Rei. Divinópolis, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de São João Del-Rei. Divinópolis, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de São João Del-Rei. Divinópolis, MG, Brasil | pt_BR |
Subject | Lippia alba | pt_BR |
Subject | Antifungal activity | pt_BR |
Subject | Yeast | pt_BR |