| Author | Sousa, Taís Nóbrega de | |
| Author | Kano, Flora Satiko | |
| Author | Brito, Cristiana Ferreira Alves de | |
| Author | Carvalho, Luzia Helena | |
| Access date | 2015-03-02T17:30:52Z | |
| Available date | 2015-03-02T17:30:52Z | |
| Document date | 2014 | |
| Citation | SOUSA, Taís Nóbrega de et al . The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon. Mem. Inst. Oswaldo Cruz, v. 109, n. 5, pp. 608-617, 2014. | pt_BR |
| ISSN | 0074-0276 | |
| URI | https://www.arca.fiocruz.br/handle/icict/9582 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz | pt_BR |
| Rights | open access | pt_BR |
| Title | The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/0074-0276130592. | |
| Abstract | Plasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (region II, DBPII) and DARC to P. vivax infection has motivated our malaria research group at Oswaldo Cruz Foundation (state of Minas Gerais, Brazil) to conduct a number of immunoepidemiological studies to characterise the naturally acquired immunity to PvDBP in populations living in the Amazon rainforest. In this review, we provide an update on the immunology and molecular epidemiology of PvDBP in the Brazilian Amazon - an area of markedly unstable malaria transmission - and compare it with data from other parts of Latin America, as well as Asia and Oceania. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratorio de Malária. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratorio de Malária. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratorio de Malária. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratorio de Malária. Belo Horizonte, MG, Brasil | pt_BR |
| Subject | malaria | pt_BR |
| Subject | Plasmodium vivax | pt_BR |
| Subject | Duffy binding protein | pt_BR |
| Subject | naturally acquired antibodies | pt_BR |
| Subject | genetic variability | pt_BR |
