| Author | Lima, Milena da Silva | |
| Author | Evangelista, Afrânio Ferreira | |
| Author | Santos, Gisele Graça Leite dos | |
| Author | Ribeiro, Ivone Maria | |
| Author | Tomassini, Therezinha Coelho Barbosa | |
| Author | Soares, Milena Botelho Pereira | |
| Author | Villarreal, Cristiane Flora | |
| Access date | 2015-03-16T17:10:14Z | |
| Available date | 2015-03-16T17:10:14Z | |
| Document date | 2014 | |
| Citation | LIMA, M. da S. et al. Antinociceptive properties of physalins from Physalis angulata. Journal of Natural Products, v. 77, n. 11, p. 2397-2403, 2014. | pt_BR |
| ISSN | 1520-6025 | |
| URI | https://www.arca.fiocruz.br/handle/icict/9708 | |
| Language | eng | pt_BR |
| Publisher | American Chemical Society and American Society of Pharmacognosy | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Dor | pt_BR |
| Subject in Portuguese | Drogas | pt_BR |
| Subject in Portuguese | Antinociceptivos | pt_BR |
| Subject in Portuguese | Camundongos | pt_BR |
| Subject in Portuguese | Physalis | pt_BR |
| Title | Antinociceptive properties of physalins from Physalis angulata. | pt_BR |
| Type | Article | pt_BR |
| DOI | org/10.1021/np5003093 | |
| Abstract | Pain is the most common reason a patient sees a physician. Nevertheless, the use of typical painkillers is not completely effective in controlling all pain syndromes; therefore further attempts have been made to develop improved analgesic drugs. The present study was undertaken to evaluate the antinociceptive properties of physalins B (1), D (2), F (3), and G (4) isolated from Physalis angulata in inflammatory and centrally mediated pain tests in mice. Systemic pretreatment with 1-4 produced dose-related antinociceptive effects on the writhing and formalin tests, traditional screening tools for the assessment of analgesic drugs. On the other hand, only 3 inhibited inflammatory parameters such as hyperalgesia, edema, and local production of TNF-α following induction with complete Freund's adjuvant. Treatment with 1, 3, and 4 produced an antinociceptive effect on the tail flick test, suggesting a centrally mediated antinociception. Reinforcing this idea, 2-4 enhanced the mice latency reaction time during the hot plate test. Mice treated with physalins did not demonstrate motor performance alterations. These results suggest that 1-4 present antinociceptive properties associated with central, but not anti-inflammatory, events and indicate a new pharmacological property of physalins. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. FarManguinhos. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. FarManguinhos. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil /Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
