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AutorLima, Milena da Silva
AutorEvangelista, Afrânio Ferreira
AutorSantos, Gisele Graça Leite dos
AutorRibeiro, Ivone Maria
AutorTomassini, Therezinha Coelho Barbosa
AutorSoares, Milena Botelho Pereira
AutorVillarreal, Cristiane Flora
Fecha de acceso2015-03-16T17:10:14Z
Fecha de disponibilización2015-03-16T17:10:14Z
Fecha de publicación2014
ReferenciaLIMA, M. da S. et al. Antinociceptive properties of physalins from Physalis angulata. Journal of Natural Products, v. 77, n. 11, p. 2397-2403, 2014.pt_BR
ISSN1520-6025
URIhttps://www.arca.fiocruz.br/handle/icict/9708
Idiomaengpt_BR
EditorAmerican Chemical Society and American Society of Pharmacognosypt_BR
Derechos de autoropen accesspt_BR
Palabras clave en PortuguésDorpt_BR
Palabras clave en PortuguésDrogaspt_BR
Palabras clave en PortuguésAntinociceptivospt_BR
Palabras clave en PortuguésCamundongospt_BR
Palabras clave en PortuguésPhysalispt_BR
TítuloAntinociceptive properties of physalins from Physalis angulata.pt_BR
Tipo del documentoArticlept_BR
DOIorg/10.1021/np5003093
Resumen en InglésPain is the most common reason a patient sees a physician. Nevertheless, the use of typical painkillers is not completely effective in controlling all pain syndromes; therefore further attempts have been made to develop improved analgesic drugs. The present study was undertaken to evaluate the antinociceptive properties of physalins B (1), D (2), F (3), and G (4) isolated from Physalis angulata in inflammatory and centrally mediated pain tests in mice. Systemic pretreatment with 1-4 produced dose-related antinociceptive effects on the writhing and formalin tests, traditional screening tools for the assessment of analgesic drugs. On the other hand, only 3 inhibited inflammatory parameters such as hyperalgesia, edema, and local production of TNF-α following induction with complete Freund's adjuvant. Treatment with 1, 3, and 4 produced an antinociceptive effect on the tail flick test, suggesting a centrally mediated antinociception. Reinforcing this idea, 2-4 enhanced the mice latency reaction time during the hot plate test. Mice treated with physalins did not demonstrate motor performance alterations. These results suggest that 1-4 present antinociceptive properties associated with central, but not anti-inflammatory, events and indicate a new pharmacological property of physalins.pt_BR
AfiliaciónUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. FarManguinhos. Rio de Janeiro, RJ, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. FarManguinhos. Rio de Janeiro, RJ, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasilpt_BR
AfiliaciónUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil /Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasilpt_BR


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