Author | Andrade, Bruno de Bezerril | |
Author | Singh, Amrit | |
Author | Narendran, Gopalan | |
Author | Schechter, Melissa E. | |
Author | Nayak, Kaustuv | |
Author | Subramanian, Sudha | |
Author | Anbalagan, Selvaraj | |
Author | Jensen, Stig M. R. | |
Author | Porter, Brian O. | |
Author | Antonelli, Lis Ribeiro do Valle | |
Author | Wilkinson, Katalin A. | |
Author | Wilkinson, Robert J. | |
Author | Meintjes, Graeme | |
Author | Plas, Helen van der | |
Author | Follmann, Dean | |
Author | Barber, Daniel L. | |
Author | Swaminathan, Soumya | |
Author | Sher, Alan | |
Author | Sereti, Irini | |
Access date | 2015-03-17T17:17:24Z | |
Available date | 2015-03-17T17:17:24Z | |
Document date | 2014 | |
Citation | ANDRADE, Bruno de Bezerril et al. Associated Immune Reconstitution Inflammatory Syndrome. PLoS Pathog, v. 10, n. 10, p. e1004433, 2014 | pt_BR |
ISSN | 1553-7366 | |
URI | https://www.arca.fiocruz.br/handle/icict/9727 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Title | Mycobacterial Antigen Driven Activation of CD14++CD162 Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.ppat.1004433 | |
Abstract | Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an aberrant inflammatory response occurring in a subset of TB-HIV co-infected patients initiating anti-retroviral therapy (ART). Here, we examined monocyte activation by prospectively quantitating pro-inflammatory plasma markers and monocyte subsets in TB-HIV co-infected patients from a South Indian cohort at baseline and following ART initiation at the time of IRIS, or at equivalent time points in non-IRIS controls. Pro-inflammatory biomarkers of innate and myeloid cell activation were increased in plasma of IRIS patients pre-ART and at the time of IRIS; this association was confirmed in a second cohort in South Africa. Increased expression of these markers correlated with elevated antigen load as measured by higher sputum culture grade and shorter duration of anti-TB therapy. Phenotypic analysis revealed the frequency of CD14++CD16− monocytes was an independent predictor of TB-IRIS, and was closely associated with plasma levels of CRP, TNF, IL-6 and tissue factor during IRIS. In addition, production of inflammatory cytokines by monocytes was higher in IRIS patients compared to controls pre-ART. These data point to a major role of mycobacterial antigen load and myeloid cell hyperactivation in the pathogenesis of TB-IRIS, and implicate monocytes and monocyte-derived cytokines as potential targets for TB-IRIS prevention or treatment. | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, United States of America | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases.Laboratory of Immunoregulation. Clinical and Molecular Retrovirology Section. Bethesda, MD, United States of America | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases.Laboratory of Immunoregulation. Clinical and Molecular Retrovirology Section. Bethesda, MD, United States of America | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases.Laboratory of Immunoregulation. Clinical and Molecular Retrovirology Section. Bethesda, MD, United States of America | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases.Laboratory of Immunoregulation. Clinical and Molecular Retrovirology Section. Bethesda, MD, United States of America | pt_BR |
Affilliation | Laboratório de Imunopatologia, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil | pt_BR |
Affilliation | University of Cape Town. Institute of Infectious Disease and Molecular Medicine, and Department of Medicine. Clinical Infectious Diseases Research Initiative. Cape Town, South Africa | pt_BR |
Affilliation | University of Cape Town. Institute of Infectious Disease and Molecular Medicine, and Department of Medicine. Clinical Infectious Diseases Research Initiative. Cape Town, South Africa/Imperial College London. Department of Medicine. London, United Kingdom/MRC National Institute for Medical Research. London, United Kingdom | pt_BR |
Affilliation | University of Cape Town. Institute of Infectious Disease and Molecular Medicine, and Department of Medicine. Clinical Infectious Diseases Research Initiative. Cape Town, South Africa/Imperial College London. Department of Medicine. London, United Kingdom | pt_BR |
Affilliation | University of Cape Town. Institute of Infectious Disease and Molecular Medicine, and Department of Medicine. Clinical Infectious Diseases Research Initiative. Cape Town, South Africa | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Biostatistics Research Branch. Bethesda, MD, United States of America | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. T-Lymphocyte Biology Unit, Laboratory of Parasitic Diseases. Bethesda, MD, United States of America | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, United States of America | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases.Laboratory of Immunoregulation. Clinical and Molecular Retrovirology Section. Bethesda, MD, United States of America | pt_BR |
Subject | diseases | pt_BR |
Subject | tuberculosis | pt_BR |